TLR10 Activators
TLR10 Activators represent a collection of chemical compounds that influence the functional activity of TLR10 through various indirect mechanisms and signaling pathways integral to the innateGiven the provided information, I will replace "protein name" with "TLR10" and "gene name" with the corresponding gene associated with TLR10. TLR10 Activators are a class of chemicals that engage with Toll-like receptor 10 (TLR10), which is part of the Toll-like receptor family known for recognizing patterns associated with microbial pathogens or cellular stress. These activators can prompt TLR10 to initiate signaling pathways that lead to the expression of genes involved in various cellular processes. TLR10 is unique among the TLR family members because its specific ligands and the complete scope of its biological functions are not as well characterized as those of other TLRs. TLR10 activators can bind directly to the receptor, causing a conformational change that triggers its dimerization with other TLRs or with itself, which is a crucial step in the signaling process. The dimerization then recruits adaptor proteins such as MyD88, leading to the activation of downstream kinase cascades.
Once these kinase cascades are activated, they can result in the translocation of transcription factors such as NF-κB into the nucleus. These transcription factors can then bind to DNA and enhance the transcription of target genes that play roles in cellular responses. The exact nature of the response can vary widely, as TLR10 is expressed in different cell types, and the context of activation can influence the outcome of gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $102.00 $306.00 $510.00 $1559.00 | 12 | |
Resiquimod is an agonist of TLR7 and TLR8, which share some signaling components with TLR10. Resiquimod enhances TLR-mediated NF-κB activation, leading to an increase in pro-inflammatory cytokine production potentially enhancing the functional activity of TLR10 by promoting shared signaling pathway components. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Poly(I:C) is a synthetic analog of double-stranded RNA, acting as an agonist for TLR3. It triggers an antiviral response by inducing the production of type I interferons and other cytokines. Cross-talk between TLR3 and TLR10 signaling pathways could result in an indirect enhancement of TLR10 activity through interferon-stimulated genes. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod is an immune response modifier that activates TLR7. By enhancing TLR7 signaling, imiquimod promotes the production of inflammatory cytokines and co-stimulatory molecule expression, which can indirectly influence TLR10 activity through the upregulation of shared signaling pathway components. | ||||||
Pam3Cys-Ser-(Lys)4, Hydrochloride | 112208-00-1 | sc-507471 | 2 mg | $550.00 | ||
Pam3CSK4 is a synthetic triacylated lipopeptide that mimics the acylated amino termini of bacterial lipoproteins, activating TLR1/TLR2 heterodimers. Since TLR10 is known to form heterodimers with TLR2, Pam3CSK4 could indirectly enhance TLR10 activity by stimulating shared adapter proteins and signaling molecules. | ||||||
Lipoteichoic acid | 56411-57-5 | sc-507479 | 5 mg | $248.00 | ||
Lipoteichoic acid from Gram-positive bacteria is recognized by TLR2, which forms heterodimers with TLR10. By activating TLR2, lipoteichoic acid can indirectly enhance the activity of TLR10 through shared signaling pathways, including the activation of NF-κB and MAPKs, which are central to the pro-inflammatory response. | ||||||