TIG1 Activators
TIG1, also known as Tazarotene-induced gene 1, is a protein whose function has garnered significant attention in recent years due to its involvement in various cellular processes, particularly those related to cellular differentiation, proliferation, and apoptosis. TIG1 belongs to the retinoid-induced class of genes. This protein exhibits tumor suppressor-like properties and is often dysregulated in various cancer types, suggesting its critical role in maintaining cellular homeostasis.
Activation of TIG1 is intricately linked to retinoid signaling pathways, particularly through the binding of retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Upon activation by their ligands, RARs and RXRs form heterodimers that bind to specific DNA sequences known as retinoic acid response elements (RAREs) located within the promoter regions of target genes, including TIG1. Activation of TIG1 transcription leads to increased protein expression, which in turn mediates its tumor suppressive functions. Additionally, TIG1 activation can also occur through post-translational modifications or interactions with other signaling molecules, further enhancing its regulatory effects on cellular processes. Understanding the mechanisms underlying TIG1 activation provides valuable insights into its role in cancer development and progression, with implications for interventions targeting TIG1 dysregulation in cancer.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tazarotene | 118292-40-3 | sc-220193 | 10 mg | $103.00 | ||
Tazarotene, a retinoic acid receptor-specific retinoid, up-regulates TIG-1 (Tazarotene-Induced Gene 1), which may mediate an antiproliferative effect in the treatment of psoriasis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA promotes TIG1 expression through its role as a ligand for retinoic acid receptors (RARs), binding to retinoic acid response elements (RAREs) in the promoter regions of target genes, including TIG1, thereby inducing transcriptional activation and leading to cell differentiation and potential anti-proliferative effects on cancer cells. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
4-Hydroxyphenylretinamide induces TIG1 expression by acting as a synthetic retinoid that interacts with retinoid receptors, modulating gene expression. This interaction results in the activation of signaling pathways that promote apoptosis and cell cycle arrest in cancer cells, positioning TIG1 as a mediator in these processes. | ||||||
Bexarotene | 153559-49-0 | sc-217753 sc-217753A | 10 mg 100 mg | $55.00 $250.00 | 6 | |
Bexarotene selectively activates retinoid X receptors (RXRs), leading to the induction of TIG1 expression. This activation involves the transcriptional regulation of genes involved in cell differentiation and apoptosis, positioning TIG1 as a key effector in the therapeutic efficacy against cutaneous T-cell lymphoma and other skin disorders. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine reactivates TIG1 expression through DNA demethylation, by inhibiting DNA methyltransferases (DNMTs), leading to a decrease in DNA methylation and allowing for the re-expression of genes like TIG1 that may be silenced in cancer cells. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid inhibits histone deacetylases (HDACs), leading to an increase in acetylated histones and chromatin relaxation, enhancing transcription. This facilitates the reactivation and increased expression of TIG1, which can lead to apoptosis and differentiation in cancer cells. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid, as an HDAC inhibitor, induces hyperacetylation of histones, promoting a more open chromatin structure that facilitates gene expression, including the upregulation of TIG1. This contributes to its potential use in targeting aberrant epigenetic modifications in cancer cells. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
Zebularine acts as a DNA demethylating agent, inhibiting DNA methyltransferases to prevent the methylation of cytosine residues, leading to decreased DNA methylation and allowing for the transcription and expression of previously silenced genes, including TIG1, which plays a role in cellular differentiation and the suppression of tumorigenesis. | ||||||