thyroid peroxidase Inhibitors
Thyroid peroxidase inhibitors are a class of chemical compounds specifically designed to target and interfere with the activity of the thyroid peroxidase (TPO) enzyme. TPO plays a crucial role in the synthesis of thyroid hormones within the thyroid gland, a process essential for regulating various physiological functions throughout the body. This class of inhibitors exerts its influence at the molecular level, impacting the intricate mechanism by which TPO facilitates the production of thyroid hormones. To comprehend their significance, it is essential to delve into the physiological processes within the thyroid gland and the central role of TPO.Within the thyroid gland, TPO is an enzyme that primarily catalyzes two key reactions during thyroid hormone synthesis: the oxidation of iodide ions (I-) to form iodine atoms (I°), and the subsequent iodination of tyrosine residues on thyroglobulin, a glycoprotein present within the thyroid follicles. These reactions are fundamental for the generation of thyroxine (T4) and triiodothyronine (T3), the two primary thyroid hormones.
Thyroid peroxidase inhibitors disrupt this process by interfering with TPO's ability to oxidize iodide ions and iodinate tyrosine residues effectively. They often compete with iodide ions for binding at the active site of the enzyme, thus impeding the iodination process. Consequently, this inhibition leads to reduced thyroid hormone production and secretion into the bloodstream, a phenomenon that can have far-reaching consequences on the body's overall metabolism and energy regulation. Thyroid peroxidase inhibitors represent a class of chemical compounds that exert their action by specifically targeting the thyroid peroxidase enzyme within the thyroid gland. By disrupting the iodination process necessary for thyroid hormone synthesis, these inhibitors effectively modulate the thyroid's ability to produce and release T3 and T4 hormones.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $69.00 $110.00 | 4 | |
Methimazole inhibits thyroid peroxidase by interfering with the oxidation of iodide ions and the subsequent iodination of tyrosine residues on thyroglobulin. This disruption reduces the synthesis of thyroid hormones T3 and T4, ultimately suppressing thyroid activity. | ||||||
Carbimazole | 22232-54-8 | sc-205620 sc-205620A | 1 g 5 g | $40.00 $130.00 | ||
Carbimazole is a prodrug that converts to Methimazole in the body. It inhibits thyroid peroxidase in the same manner as Methimazole, preventing the iodination of tyrosine residues on thyroglobulin and subsequently reducing thyroid hormone synthesis. | ||||||
Imidazole | 288-32-4 | sc-204776 sc-204776A sc-204776B sc-204776C | 25 g 100 g 1 kg 5 kg | $26.00 $55.00 $82.00 $336.00 | 2 | |
Imidazole derivatives can act as thyroid peroxidase inhibitors by competing with iodide ions at the enzyme's active site. They interfere with iodination reactions, effectively decreasing the production of thyroid hormones. | ||||||
Thiourea | 62-56-6 | sc-213038 | 50 g | $37.00 | ||
Various thiourea derivatives can inhibit thyroid peroxidase by disrupting the iodination of tyrosine residues on thyroglobulin. They compete with iodide ions at the enzyme's active site and reduce the synthesis of thyroid hormones. | ||||||
6-(Methylthio)purine | 50-66-8 | sc-268183 | 100 mg | $168.00 | ||
6-Methylthiopurine is an inhibitor of thyroid peroxidase that acts by interfering with the iodination of tyrosine residues on thyroglobulin. It competes with iodide ions for binding at the active site of the enzyme, reducing the synthesis of thyroid hormones. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $36.00 $55.00 $220.00 $1958.00 | ||
6-N-Propyl-2-thiouracil is a thyroid peroxidase inhibitor that disrupts the iodination of tyrosine residues on thyroglobulin. It competes with iodide ions for binding to the enzyme's active site, thereby reducing the production of T3 and T4 hormones. | ||||||
O-(Carboxymethyl)hydroxylamine hemihydrochloride | 2921-14-4 | sc-207410B sc-207410 sc-207410A | 250 mg 1 g 10 g | $54.00 $105.00 $314.00 | ||
Aminooxyacetic acid acts as a thyroid peroxidase inhibitor by interfering with the enzyme's ability to incorporate iodine into tyrosine residues on thyroglobulin. It disrupts iodination reactions and reduces the synthesis of thyroid hormones T3 and T4. | ||||||