THEM92 Inhibitors

TMEM92 inhibitors are compounds that can affect the function or expression of transmembrane proteins indirectly. These chemicals rely on the potential interactions or effects on general transmembrane proteins or cellular membranes. For instance, compounds like Chlorpromazine are known to alter membrane fluidity, which can influence the function or localization of transmembrane proteins like TMEM92.

Similarly, calcium channel blockers such as Verapamil and Nifedipine might indirectly affect TMEM92 by modulating the activity of certain membrane proteins. On the other hand, drugs like Filipin, which disrupt lipid rafts, can affect the microenvironment of transmembrane proteins and thus their functionality. Additionally, ion channel inhibitors, such as Amiloride or DIDS, by modifying ion homeostasis, can potentially influence the function or expression of proteins like TMEM92.