TCF-3 Inhibitors
TCF-3 inhibitors constitute a class of chemicals that exert their regulatory effects on the transcription factor TCF-3 by targeting key components of the Wnt signaling pathway. These inhibitors modulate TCF-3 indirectly by influencing the canonical Wnt pathway, which plays a pivotal role in cellular processes such as embryonic development and tissue homeostasis. For instance, XAV-939 stabilizes Axin through tankyrase inhibition, promoting β-catenin degradation and affecting TCF-3's transcriptional activity. Similarly, FH535, a dual inhibitor, impacts both Wnt and PPAR pathways, indirectly influencing TCF-3 by disrupting Wnt signaling and associated cellular processes.
These TCF-3 inhibitors exhibit specificity in their mechanisms, targeting crucial interactions like the β-catenin/TCF complex or stabilizing Axin to modulate Wnt signaling. As a consequence, TCF-3's role in regulating gene expression within the Wnt pathway is altered. Understanding the detailed biochemical and cellular pathways affected by these inhibitors provides insights into their specific modes of action, laying the foundation for further exploration of their ability in various cellular contexts.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV-939 inhibits tankyrase, a regulator of the Wnt pathway. By stabilizing Axin, it promotes β-catenin degradation, indirectly inhibiting TCF-3, a downstream effector of Wnt signaling. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $182.00 $374.00 | 7 | |
FH535 functions as a dual inhibitor, targeting both Wnt and peroxisome proliferator-activated receptor (PPAR). It indirectly modulates TCF-3 by influencing Wnt signaling and related cellular processes. | ||||||
JW 55 | 664993-53-7 | sc-364517 sc-364517A | 10 mg 50 mg | $172.00 $726.00 | ||
JW55 is a tankyrase inhibitor, impacting the canonical Wnt pathway. By stabilizing Axin, it indirectly inhibits TCF-3, which relies on the β-catenin-dependent transcription for its regulatory role. | ||||||
KY02111 | 1118807-13-8 | sc-397043 sc-397043A | 5 mg 25 mg | $79.00 $336.00 | ||
KY02111 inhibits Wnt/β-catenin signaling by preventing the interaction between β-catenin and TCF-3. It directly interferes with the transcriptional activity of TCF-3 within the Wnt signaling cascade. | ||||||
IQ-1 | 331001-62-8 | sc-202665 | 10 mg | $180.00 | 2 | |
IQ1 targets the Wnt pathway by inhibiting the β-catenin-TCF interaction. This indirect inhibition affects TCF-3, a crucial downstream mediator of Wnt signaling, modulating its transcriptional functions. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $260.00 | ||
PRI-724 interferes with the interaction between β-catenin and CBP, disrupting Wnt signaling. Through this disruption, it indirectly influences TCF-3, altering its involvement in transcriptional regulation. | ||||||
NSC 668036 | 144678-63-7 | sc-507412 | 5 mg | $175.00 | ||
NSC668036 inhibits the interaction between β-catenin and TCF-3, hindering Wnt signaling. This disruption directly impacts TCF-3's ability to regulate gene expression within the Wnt pathway. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1-endo is a tankyrase inhibitor that stabilizes Axin, promoting β-catenin degradation. This indirect modulation of Wnt signaling influences TCF-3, a downstream component of this signaling pathway. | ||||||
CCT036477 | 305372-78-5 | sc-391631A sc-391631 | 5 mg 25 mg | $109.00 $437.00 | 1 | |
CCT036477 is a tankyrase inhibitor that stabilizes Axin, indirectly inhibiting Wnt signaling. This modulation affects TCF-3, impacting its role in transcriptional regulation within the Wnt pathway. | ||||||
G007-LK | 1380672-07-0 | sc-507467 | 1 mg | $48.00 | ||
G007-LK targets tankyrase, promoting Axin stabilization and β-catenin degradation. Through this indirect mechanism, it modulates TCF-3, a downstream effector of the Wnt signaling pathway. | ||||||