Tas2r125 Activators
Chemical activators of Tas2r125 include a range of compounds that interact with the protein's receptor sites to induce the perception of bitterness. Denatonium, known for being one of the most bitter substances, activates Tas2r125 by binding to its bitter taste receptor sites, leading to a conformational change in the protein's structure. This change triggers signaling pathways associated with taste transduction, such as the activation of phospholipase C, which then produces inositol trisphosphate and leads to an increase in intracellular calcium levels. Similarly, phenylthiocarbamide (PTC) and propylthiouracil bind directly to Tas2r125, activating a G-protein signaling pathway that modulates ion channels and cellular responses, culminating in the bitter taste sensation.
Other compounds, like saccharin, quinine, caffeine, acesulfame K, and sucralose, activate Tas2r125 through direct interaction with the receptor's binding sites. Saccharin and acesulfame K initiate a G-protein-coupled receptor cascade, resulting in the release of gustducin and the activation of downstream effectors involved in taste perception. Quinine and caffeine similarly mimic natural bitter ligands of Tas2r125, prompting the activation of signaling molecules like the alpha gustducin protein, which is integral to bitter taste signal transduction. Natural compounds such as glycyrrhizin, naringin, amarogentin, and absinthin also activate Tas2r125 by binding to its active sites, triggering G-protein-coupled signaling pathways that contribute to the sensation of bitterness. These chemical interactions with Tas2r125 enable the detection of a wide variety of bitter compounds, which is a critical function of the taste system.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Denatonium benzoate | 3734-33-6 | sc-234525 sc-234525A sc-234525B sc-234525C sc-234525D | 1 g 5 g 25 g 100 g 250 g | $32.00 $47.00 $141.00 $473.00 $921.00 | ||
Denatonium activates Tas2r125 by binding to its bitter taste receptor sites. This interaction leads to a change in the tertiary structure of the protein, which then activates signaling pathways associated with taste transduction, such as the increase in intracellular calcium levels that result from the activation of phospholipase C and the subsequent production of inositol trisphosphate. | ||||||
Saccharin | 81-07-2 | sc-212902 sc-212902A sc-212902B | 100 mg 1 g 10 g | $173.00 $235.00 $286.00 | ||
Saccharin, a synthetic sweetener, activates Tas2r125 by directly interacting with the receptor's binding sites. This binding event triggers Tas2r125 to initiate a G-protein-coupled receptor cascade, resulting in the release of gustducin and the activation of downstream effectors that lead to taste perception. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $79.00 $104.00 $166.00 $354.00 $572.00 | 1 | |
Quinine is an alkaloid that activates Tas2r125 by direct binding to the bitter taste receptor, leading to the activation of the protein and its associated G-protein-coupled signaling pathways. The activation of these pathways culminates in the release of neurotransmitters that convey the sensation of bitterness. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine activates Tas2r125 by mimicking the natural bitter ligands of the receptor, thereby inducing the activation of downstream signaling molecules involved in taste perception, such as the alpha gustducin protein, which plays a role in bitter taste signal transduction. | ||||||
N-Phenylthiourea | 103-85-5 | sc-236086 | 100 g | $319.00 | ||
Phenylthiocarbamide (PTC) activates Tas2r125 by binding to the bitter taste receptors and initiating a G-protein signaling pathway. The interaction with Tas2r125 leads to the activation of adenylate cyclase inhibited pathway, which in turn modulates ion channels and cellular responses that contribute to the bitter taste sensation. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $37.00 $56.00 $224.00 $1997.00 | ||
Propylthiouracil activates Tas2r125 by directly binding to the receptor, which then leads to the activation of the protein and its associated signaling pathways, ultimately triggering the bitter taste signaling cascade. | ||||||
Acesulfame Potassium | 55589-62-3 | sc-210736 | 25 g | $245.00 | ||
Acesulfame K activates Tas2r125 through direct interaction with the receptor's ligand-binding domain, initiating the activation of taste receptor cells via G-protein-coupled signaling pathways. This interaction results in the perception of a bitter taste. | ||||||
Sucralose | 56038-13-2 | sc-222332 sc-222332A | 100 mg 1 g | $133.00 $463.00 | ||
Sucralose activates Tas2r125 by binding to the receptor's extracellular domain, resulting in the activation of taste transduction pathways that lead to the perception of bitterness, despite its inherent sweetness. | ||||||
Naringin | 10236-47-2 | sc-203443 sc-203443A | 25 g 50 g | $45.00 $101.00 | 7 | |
Naringin, a flavonoid found in grapefruits, activates Tas2r125 by binding to the bitter taste receptor, which induces the activation of the protein and its associated signaling pathways, contributing to the perception of bitterness. | ||||||