TAF I p110_TAF I p95 Inhibitors

TAF I p110 and TAF I p95 inhibitors constitute a specialized chemical class of molecules designed to target specific proteins involved in transcriptional regulation and chromatin remodeling within the cell. TAF I p110 and TAF I p95 are subunits of the TFIID complex, which is an integral part of the transcription machinery responsible for initiating the transcription of protein-coding genes. These subunits play crucial roles in regulating gene expression by assisting in the assembly of the pre-initiation complex at gene promoters. TAF I p110, also known as TAF6, and TAF I p95, also known as TAF9, contribute to the stability and function of the TFIID complex, facilitating the recruitment of RNA polymerase II and other transcription factors to the promoter region of genes.

Inhibitors targeting TAF I p110 and TAF I p95 are designed to interfere with the interactions between these subunits and other components of the transcriptional machinery, disrupting the proper assembly and function of the TFIID complex. By modulating the activity of these key transcriptional regulators, these inhibitors can impact gene expression patterns and cellular responses to various environmental signals. Research on TAF I p110 and TAF I p95 inhibitors is primarily focused on advancing our understanding of the intricate mechanisms underlying gene transcription and chromatin dynamics within the nucleus, with implications for a wide range of biological processes.