TADA2L Inhibitors
TADA2L inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the TADA2L (Transcriptional Adaptor 2-Like) protein, which is a component of the ADA (Alteration/Deficiency in Activation) complex. The ADA complex plays a key role in gene expression by facilitating chromatin remodeling, thereby promoting transcriptional activation. TADA2L is involved in this process by acting as an adaptor protein that mediates the interaction between other components of the ADA complex and transcriptional machinery. Inhibitors of TADA2L function by disrupting its ability to participate in these protein-protein interactions, leading to alterations in gene expression by blocking the activation of specific transcriptional programs. This inhibition directly affects how genes are turned on or off in response to various cellular signals.
Research into TADA2L inhibitors provides critical insights into the regulatory mechanisms that control chromatin structure and gene transcription. By inhibiting TADA2L, scientists can explore how the disruption of the ADA complex affects chromatin accessibility and the transcription of target genes. This research is valuable for understanding the specific role of TADA2L in facilitating transcriptional co-activation, as well as its involvement in broader chromatin remodeling processes. The study of TADA2L inhibitors also helps uncover the molecular mechanisms by which chromatin remodeling complexes, such as the ADA complex, interact with the transcriptional machinery and regulate gene expression. These inhibitors are essential tools for studying the dynamic control of gene expression and the ways in which cellular responses are modulated by chromatin structure and remodeling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a natural compound found in turmeric. It has been shown to inhibit the activity of histone acetyltransferases (HATs), which are enzymes involved in chromatin remodeling and gene expression regulation. TADA2L is a component of the TFIID complex, which recruits HATs to the promoter regions of genes. By inhibiting HAT activity with curcumin, it can potentially disrupt the recruitment of TADA2L and hinder its function in gene expression regulation. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Anacardic acid is a natural compound found in cashew nuts. It has been shown to inhibit the activity of HATs, including p300/CBP, which are involved in chromatin remodeling and gene expression regulation. TADA2L interacts with p300/CBP and is involved in the transcriptional activation of genes. By inhibiting p300/CBP activity with anacardic acid, it can potentially disrupt the interaction with TADA2L and impair its function in gene expression regulation. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 is a selective inhibitor of the histone acetyltransferase p300/CBP-associated factor (PCAF). TADA2L interacts with PCAF and is involved in the transcriptional activation of genes. By inhibiting PCAF activity with C646, it can potentially disrupt the interaction with TADA2L and hinder its function in gene expression regulation. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $136.00 $492.00 | 13 | |
Garcinol is a natural compound found in Garcinia indica. It has been shown to inhibit the activity of HATs, including p300/CBP. TADA2L interacts with p300/CBP and is involved in the transcriptional activation of genes. By inhibiting p300/CBP activity with garcinol, it can potentially disrupt the interaction with TADA2L and impair its function in gene expression regulation. | ||||||
I-CBP112 | 1640282-31-0 | sc-507494 | 25 mg | $400.00 | ||
I-CBP112 is a selective inhibitor of the bromodomain-containing protein 4 (BRD4), which interacts with TADA2L. BRD4 is involved in the regulation of gene expression and chromatin remodeling. By inhibiting BRD4 activity with I-CBP112, it can potentially disrupt the interaction with TADA2L and hinder its function in gene expression regulation. | ||||||
GSK-J4 | 1373423-53-0 | sc-507551 | 100 mg | $1275.00 | ||
GSK-J4 is a selective inhibitor of the histone demethylase JMJD3. TADA2L interacts with JMJD3 and is involved in the regulation of gene expression. By inhibiting JMJD3 activity with GSK-J4, it can potentially disrupt the interaction with TADA2L and hinder its function in gene expression regulation. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
EPZ004777 is a selective inhibitor of the histone methyltransferase DOT1L. TADA2L is involved in the recruitment of DOT1L to gene promoters and the regulation of gene expression. By inhibiting DOT1L activity with EPZ004777, it can potentially disrupt the recruitment of TADA2L and impair its function in gene expression regulation. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
UNC1999 is a selective inhibitor of the histone methyltransferase EZH2. TADA2L interacts with EZH2 and is involved in the regulation of gene expression. By inhibiting EZH2 activity with UNC1999, it can potentially disrupt the interaction with TADA2L and hinder its function in gene expression regulation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a selective inhibitor of the bromodomain and extraterminal domain (BET) proteins, including BRD4. TADA2L interacts with BRD4 and is involved in the regulation of gene expression. By inhibiting BRD4 activity with JQ1, it can potentially disrupt the interaction with TADA2L and impair its function in gene expression regulation. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 free base | sc-202651 | 5 mg | $148.00 | 4 | |
BIX-01294 is a selective inhibitor of the histone methyltransferase G9a/GLP. TADA2L interacts with G9a/GLP and is involved in the regulation of gene expression. By inhibiting G9a/GLP activity with BIX-01294, it can potentially disrupt the interaction with TADA2L and hinder its function in gene expression regulation. | ||||||