Streptolysin Activators
Calcium ions play a crucial role in the activation of Streptolysin. Binding of calcium ions to Streptolysin triggers conformational changes that enable the toxin to form pores in the host cell membrane. This direct interaction between calcium ions and Streptolysin enhances its functional activity by promoting its structural rearrangement and subsequent pore formation. Moreover, phosphatidylcholine, phosphatidylinositol, and lysophosphatidylcholine, which are major phospholipid components of cell membranes, can directly interact with Streptolysin and facilitate its binding and insertion into the host cell membrane. This interaction enhances the functional activation of Streptolysin and promotes cell lysis.
In summary, Streptolysin is activated and its functional activity is enhanced through direct interactions with various components of the host cell membrane, including sphingomyelinase, sphingosine, sialic acid, glycosphingolipids, calcium ions, phosphatidylcholine, phosphatidylinositol, and lysophosphatidylcholine. These interactions lead to the formation of pores in the cell membrane, resulting in cell lysis and the release of intracellular contents.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Calcium ions play a crucial role in the activation of Streptolysin. Binding of calcium ions to Streptolysin triggers conformational changes that enable the toxin to form pores in the host cell membrane. The presence of calcium ions can directly enhance the functional activity of Streptolysin by promoting its structural rearrangement and subsequent pore formation. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
Sphingosine is a bioactive lipid that can modulate various cellular processes. It has been shown that sphingosine can enhance the activity of Streptolysin by promoting its binding to the host cell membrane. This direct interaction between sphingosine and Streptolysin can lead to the functional activation of the toxin and subsequent cell lysis. | ||||||
L-α-Lysophosphatidylcholine (from egg yolk) | 9008-30-4 | sc-473611 sc-473611A sc-473611B sc-473611C | 25 mg 100 mg 500 mg 1 g | $87.00 $235.00 $607.00 $1102.00 | 1 | |
Lysophosphatidylcholine is a lipid molecule that can be generated by the hydrolysis of phosphatidylcholine. It has been reported that lysophosphatidylcholine can directly enhance the activity of Streptolysin by promoting its binding and insertion into the host cell membrane. This interaction can lead to the functional activation of Streptolysin and subsequent cell lysis. | ||||||
N-Acetylneuraminic acid | 131-48-6 | sc-281055A sc-281055 sc-281055D sc-281055B sc-281055C | 1 g 5 g 25 g 100 g 250 g | $84.00 $156.00 $326.00 $572.00 $1363.00 | ||
Sialic acid is a sugar molecule that is present on the surface of many cells. It has been shown that Streptolysin can specifically bind to sialic acid residues on the host cell membrane, leading to its functional activation. This direct interaction between sialic acid and Streptolysin can enhance its activity and promote cell lysis. | ||||||