SMG8 Activators
The class of SMG8 activators focuses on compounds that can generally affect mRNA stability, the NMD pathway, and related cellular processes, thereby influencing the function or expression of SMG8 indirectly. Compounds like cycloheximide and emetine, which inhibit protein synthesis, can be used to study the effects on NMD efficiency and thereby provide insights into the functional aspects of SMG8 within this pathway.
Additionally, agents that affect mRNA synthesis, processing, and splicing, such as Actinomycin D and Spliceostatin A, might have indirect effects on the NMD pathway and SMG8 function. While these compounds can provide insights into mRNA stability and decay mechanisms, their specific effects on SMG8 are not well-established. Therefore, targeted research and development are necessary to discover direct activators or specific modulators for SMG8, contributing to a more precise understanding of its biological functions and potential roles in the nonsense-mediated mRNA decay pathway.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Inhibits DNA-dependent RNA synthesis, impacting mRNA synthesis and potentially NMD processes involving SMG8. | ||||||
Amlexanox | 68302-57-8 | sc-217630 | 10 mg | $160.00 | 2 | |
An inhibitor of TBK1 and IKK-ε, potentially influencing signaling pathways that intersect with NMD and SMG8 function. | ||||||
Geneticin (G418) Sulfate | 108321-42-2 | sc-29065 sc-29065A sc-29065C sc-29065D sc-29065B | 1 g 5 g 100 g 500 g 25 g | $108.00 $399.00 $1530.00 $6248.00 $469.00 | 193 | |
An aminoglycoside antibiotic, induces read-through of premature stop codons, potentially affecting NMD and SMG8. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Affects lysosomal function and autophagy, potentially influencing cellular pathways that interact with NMD and SMG8. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, could influence signaling pathways and cellular processes relevant to NMD and SMG8. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
Affects mRNA splicing, potentially influencing the generation of NMD substrates and indirectly affecting SMG8. | ||||||