SIP1 Activators
Common SIP1 Activators include, but are not limited to Cobalt(II) chloride CAS 7646-79-9, Retinoic Acid, all trans CAS 302-79-4, Dimethyloxaloylglycine (DMOG) CAS 89464-63-1, Curcumin CAS 458-37-7 and Trichostatin A CAS 58880-19-6.
The chemical class of SIP1 Activators are compounds that interact with and modulate the activity of SMAD-interacting protein 1 (SIP1), also known as ZEB2 (zinc finger E-box-binding homeobox 2). SIP1 is a transcription factor that plays a vital role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis. SIP1 is known for its involvement in epithelial-mesenchymal transition (EMT), a cellular process crucial for embryogenesis and tissue repair, as well as in pathological conditions such as cancer metastasis and fibrosis. SIP1 Activators are designed to influence the transcriptional activity of SIP1 and thereby impact downstream gene expression programs regulated by this protein.
The modulation of SIP1 activity by SIP1 Activators holds significant implications for understanding cellular plasticity and its role in development. By altering SIP1's transcriptional activity, researchers can gain insights into the molecular mechanisms underlying processes like EMT and cellular differentiation, which are essential for tissue morphogenesis and repair. The study of SIP1 Activators is an active area of research aimed at deciphering the intricate regulatory networks that govern cellular plasticity and uncovering novel strategies for addressing related pathologies.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
Cobalt chloride is a chemical compound that can induce hypoxia-mimicking conditions by stabilizing hypoxia-inducible factors (HIFs). HIFs can upregulate SIP1 expression as part of cellular responses to low oxygen levels, a process linked to adaptations to hypoxic stress. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA is a derivative of vitamin A and functions as a transcriptional regulator. ATRA signaling can influence SIP1 expression, affecting processes such as cell differentiation and embryonic development. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $84.00 $301.00 $374.00 $779.00 | 25 | |
DMOG is a prolyl hydroxylase inhibitor that stabilizes HIFs, inducing a hypoxia-like response. This response can lead to the upregulation of SIP1 expression as part of cellular adaptations to hypoxic conditions. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural compound with potential transcription factor modulation activity. It might indirectly influence SIP1 expression by affecting regulatory networks that involve SIP1-related transcription factors. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is an HDAC inhibitor that increases histone acetylation, leading to changes in chromatin structure. This can facilitate the binding of transcription factors to the SIP1 gene promoter, enhancing SIP1 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine inhibits DNA methylation, which can impact gene expression. By demethylating regulatory regions of the SIP1 gene, Decitabine could lead to increased SIP1 expression. | ||||||