Santa Cruz Biotechnology offers a variety of gene editing products to target signaling intermediates using the CRISPR/Cas9 system. Signaling intermediates can respond to a broad range of ligand activated receptor tyrosine kinases where phosphorylation events play a pivotal role. For a well-known example, the Shc gene encodes three widely expressed proteins which act as substrates for receptors and tyrosine kinases in signal transduction pathways. Growth factor receptors with tyrosine kinase activity phosphorylate and thus modulate the function of Shc. To knockdown expression of signaling intermediates, Santa Cruz Biotechnology offers target-specific CRISPR/Cas9 Knockout (KO) Plasmids and CRISPR Double Nickase Plasmids.To activate transcription of signaling intermediate genes, Santa Cruz Biotechnology offers target-specific CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems and CRISPR Lenti Activation Systems.