SETD5 Activators
SETD5 Activators are a class of compounds that influence the biochemical and cellular pathways with the potential to modulate the functional activity of the SETD5 protein. These activators do not bind directly to SETD5 but instead modulate the epigenetic landscape in which SETD5 operates. By altering DNA and histone methylation and acetylation states, they could indirectly affect the regulatory roles of SETD5 in gene expression. The functional mechanisms of these compounds include inhibition of DNA methyltransferases, provision of methyl donor groups required for transmethylation reactions, support for methylation cycle intermediates, and modulation of histone deacetylation processes. Each chemical works within the cell's intricate network of metabolic and epigenetic pathways to potentially alter the chromatin state, making target genes more or less accessible for transcriptional regulation by SETD5.
Given that SETD5's precise activation mechanisms are not well-defined, the term SETD5 Activatorsprimarily refers to compounds that influence the epigenetic environment and DNA accessibility. These activators could lead to a more transcriptionally active chromatin conformation, indirectly promoting the function of SETD5 as a transcriptional regulator. The specificity of these activators arises from their role in modulating the methylation and acetylation landscape, which is closely related to SETD5's activity in gene regulation. The importance of understanding the functional mechanisms of these chemicals lies in their potential to modulate the regulatory processes that SETD5 is a part of, rather than directly altering its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a cytidine analog that incorporates into DNA and RNA. It acts as a DNA methyltransferase inhibitor, reducing DNA methylation. This can lead to a more open chromatin state, potentially affecting the transcriptional regulation activities of SETD5 by altering its genomic context and the availability of its target genes for transcription. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
S-Adenosylmethionine serves as a methyl donor for transmethylation reactions, including histone methylation. It could enhance SETD5 function indirectly by providing the necessary methyl groups for histone modifications that SETD5 may recognize or interact with during chromatin remodeling activities. | ||||||
Mecobalamin | 13422-55-4 | sc-211781 | 10 mg | $300.00 | ||
Mecobalamin (Methylcobalamin) is a form of vitamin B12 that serves as a cofactor for methionine synthase in the synthesis of methionine, the precursor to S-Adenosylmethionine. By supporting the cellular pool of S-Adenosylmethionine, it could indirectly influence SETD5 activity by affecting histone and DNA methylation patterns. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide is a form of vitamin B3 and a precursor to NAD+, a coenzyme involved in redox reactions. It is also an inhibitor of sirtuins, a class of deacetylases. Inhibition of deacetylation can lead to alterations in histone acetylation, potentially affecting SETD5's genomic context and modulating its activity in gene regulation. | ||||||