SEMA5A Activators

Semaphorin 5A (SEMA5A) is a protein that belongs to the semaphorin family, which is characterized by its role in axonal guidance during neural development. SEMA5A is a secreted and membrane-associated protein that exerts its effects by binding to plexin and neuropilin receptors, influencing neuronal navigation and positioning. Its structure includes a sema domain, which is a common feature in the semaphorin family and is crucial for its signaling function.Beyond its well-established role in the nervous system, SEMA5A is also involved in the immune system, where it regulates immune cell migration and activation. In the context of development, SEMA5A contributes to the patterning of neuronal circuits and has implications in angiogenesis, guiding the growth of blood vessels.

Dysregulation of SEMA5A has been associated with various pathological conditions. In particular, it has been linked to neurodevelopmental disorders, such as autism, where altered SEMA5A expression may disrupt neural connectivity. Additionally, SEMA5A has been implicated in cancer biology, where it can influence tumor angiogenesis and metastasis.SEMA5A's complex role in both health and disease makes it a target of interest for research. Understanding its signaling pathways could lead to novel interventions for neurodevelopmental disorders and cancer.