SAP 130 Activators
SAP130 activators are compounds that affect the methylation status of DNA and histones, since these epigenetic modifications can influence the repression capabilities of the Sin3A co-repressor complex. The compounds can be connected to the increase in methylation either through providing methyl donor substrates such as S-Adenosylmethionine or enhancing the synthesis of such substrates via vitamins like B12, Folic Acid, and B6.
In contrast, compounds like RG108 can modulate methylation patterns, which may indirectly lead to a cellular environment that supports the function of the Sin3A complex. It is worth noting that the context and the specific cellular environment are crucial for the effects of these compounds, as they can have varying outcomes based on the cell type and the state of differentiation or activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
Serves as a methyl donor for DNA and histone methyltransferases, potentially supporting a chromatin state that is conducive to Sin3A complex recruitment and SAP130 function. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Involved in the generation of S-adenosylmethionine, a methyl donor for methylation processes that can impact Sin3A complex activity. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
An essential amino acid that is a precursor to S-adenosylmethionine, it can support methylation reactions that influence chromatin structure. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
A histone methyltransferase inhibitor that could potentially increase repressive histone marks and thus enhance Sin3A complex recruitment, affecting SAP130 function. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A DNA methyltransferase inhibitor that could, in certain contexts, lead to changes in DNA methylation patterns favoring Sin3A complex activity. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
A form of vitamin B3 and an inhibitor of sirtuin HDACs, which could increase DNA methylation by decreasing NAD+ levels, affecting chromatin structure. | ||||||
Procaine | 59-46-1 | sc-296134 sc-296134A sc-296134B sc-296134C | 25 g 50 g 500 g 1 kg | $110.00 $193.00 $407.00 $628.00 | 1 | |
A DNA demethylase inhibitor that could potentially lead to increased methylation status, potentially favoring Sin3A complex function. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A hypomethylating agent that in specific contexts might lead to compensatory mechanisms that enhance methylation elsewhere, possibly affecting Sin3A recruitment. | ||||||
Pyridoxine Hydrochloride | 58-56-0 | sc-219674 | 10 mg | $42.00 | ||
A coenzyme for enzymes involved in methylation processes, which can influence the activity of Sin3A-associated protein complexes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of vitamin A that can influence gene expression and chromatin structure, potentially modifying the recruitment of SAP130-containing co-repressor complexes. | ||||||