S-100A3 Inhibitors

S-100A3 inhibitors primarily focus on chemicals that can indirectly inhibit the protein by influencing calcium signaling pathways or cellular calcium homeostasis. S-100 proteins, including S-100A3, typically function as calcium-binding proteins that play a role in various cellular processes. Therefore, modulation of intracellular calcium levels or calcium signaling pathways can have a consequential impact on the activity of S-100A3.

Calcium channel blockers such as Cilnidipine, Amlodipine, Nimodipine, and Verapamil function by inhibiting the influx of calcium ions through voltage-gated calcium channels. This inhibition can alter the intracellular calcium concentration, which is crucial for the function of calcium-dependent proteins like S-100A3. By modulating the calcium levels, these inhibitors indirectly influence the activity of S-100A3, potentially leading to a decrease in its regulatory functions within the cell. Compounds like Thapsigargin and Ryanodine target the storage and release of calcium within cellular compartments. Thapsigargin inhibits the Sarco/Endoplasmic Reticulum Calcium ATPase (SERCA), leading to a disruption of calcium homeostasis in the endoplasmic reticulum, while Ryanodine modulates the release of calcium from the sarcoplasmic and endoplasmic reticulum. These actions result in altered calcium signaling, indirectly affecting S-100.