Ribosomal Protein S3A Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $163.00 $316.00 | 436 | |
Puromycin inhibits Ribosomal Protein S3A by causing premature chain termination during translation. It mimics an aminoacyl-tRNA and incorporates into the nascent protein chain causing the release of the incomplete protein. This directly inhibits the ribosome's function, where Ribosomal Protein S3A plays a critical role. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin binds to the 60S subunit of the ribosome, which affects peptidyl transferase activity, leading to the inhibition of peptide bond formation. Since Ribosomal Protein S3A is part of the ribosome and is necessary for protein synthesis, its function is directly inhibited by anisomycin's action. | ||||||
α-Sarcin | 86243-64-3 | sc-204427 | 1 mg | $316.00 | 6 | |
α-Sarcin catalyzes the cleavage of a specific phosphodiester bond in the ribosomal RNA of the large ribosomal subunit. This disrupts the ribosome's function and, consequently, inhibits the function of Ribosomal Protein S3A as part of the ribosomal machinery. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide blocks the translocation step in protein synthesis on ribosomes by binding to the eEF2 (elongation factor 2), effectively inhibiting the peptidyl transferase activity of the ribosome. This inhibition affects the function of Ribosomal Protein S3A, as it is part of the ribosomal complex essential for protein elongation. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $352.00 $566.00 $1331.00 $2453.00 | ||
Emetine inhibits protein synthesis by binding to the 40S ribosomal subunit, and thus, indirectly inhibits the function of Ribosomal Protein S3A by preventing its involvement in translation elongation. | ||||||
Harringtonin | 26833-85-2 | sc-204771 sc-204771A sc-204771B sc-204771C sc-204771D | 5 mg 10 mg 25 mg 50 mg 100 mg | $195.00 $350.00 $475.00 $600.00 $899.00 | 30 | |
Harringtonine inhibits protein synthesis by preventing the initial elongation step of translation. It binds to the 60S ribosomal subunit and inhibits the peptidyl transferase center, thus indirectly inhibiting the function of Ribosomal Protein S3A in the ribosome. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $51.00 $123.00 $178.00 | 11 | |
Homoharringtonine inhibits protein chain elongation by binding to the A-site of the ribosome, resulting in the inhibition of peptide bond formation. This action indirectly inhibits Ribosomal Protein S3A by preventing its normal function during translation elongation. | ||||||
Blasticidin S Hydrochloride | 3513-03-9 | sc-204655A sc-204655 | 25 mg 100 mg | $360.00 $475.00 | 20 | |
Blasticidin S inhibits protein synthesis by acting on both the peptidyl transferase and the exit tunnel of the ribosome. As Ribosomal Protein S3A is critical for the ribosome's protein synthesis function, blasticidin S's action results in its functional inhibition. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Chloramphenicol binds reversibly to the 50S subunit of the bacterial ribosome, inhibiting peptidyl transferase activity and thus protein synthesis. While Ribosomal Protein S3A is a eukaryotic protein, in a bacterial context, chloramphenicol's mode of action can be extrapolated to suggest that any compound that can inhibit the peptidyl transferase center would also inhibit the function of Ribosomal Protein S3A in a eukaryotic ribosome by preventing translation elongation. | ||||||