RIBC2 Inhibitors

TRIB proteins, short for "tribbles homolog," are a family of proteins that play a significant role in various cellular processes, including signaling pathways that regulate cell proliferation, differentiation, and metabolism. The name "tribbles" originates from a Drosophila melanogaster gene identified for its role in embryonic patterning. In humans, the TRIB family consists of three members: TRIB1, TRIB2, and TRIB3, each encoded by a corresponding gene TRIB1, TRIB2, and TRIB3, respectively.

TRIB proteins are characterized by a distinctive pseudokinase domain, which means they share structural similarity with kinases but generally lack enzymatic activity. Despite this, they interact with and modulate the activity of actual kinases and other signaling proteins, often acting as adaptors or scaffold proteins to regulate signal transduction pathways.TRIB1 has been implicated in lipid metabolism and is associated with conditions such as hyperlipidemia and coronary artery disease. It modulates pathways that involve key regulators of lipid metabolism, such as C/EBP alpha and signaling cascades involving MAPKs.TRIB2 is known to affect cell differentiation and has been linked to various cancers. It can influence the degradation of the transcription factor C/EBP alpha, thus affecting myeloid differentiation and contributing to the development of acute myeloid leukemia.