Date published: 2025-10-15

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Ret Inhibitors

RET inhibitors represent a class of compounds specifically designed to target the rearranged during transfection (RET) kinase. The RET protein belongs to the family of receptor tyrosine kinases (RTKs) and plays a crucial role in cellular signaling, particularly in the development and function of neural cells in embryos and the maintenance of neuronal networks in adults. However, when RET becomes abnormally activated due to mutations or other factors, it can lead to uncontrolled cellular growth and proliferation, contributing to the development and progression of certain cancers, particularly thyroid cancers and non-small cell lung cancers. RET inhibitors are meticulously crafted molecules engineered to bind selectively to the active site of RET kinase, aiming to disrupt its enzymatic activity and impede the aberrant signaling pathways associated with cancer progression driven by RET mutations. Chemically, RET inhibitors are developed through rigorous research and computational modeling to identify and design molecules capable of effectively interacting with the three-dimensional structure of the RET kinase. These inhibitors often possess a specific configuration and molecular features that enable them to fit into the binding pocket of the kinase, obstructing its function without significantly affecting other cellular processes.

Items 11 to 17 of 17 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Motesanib Diphosphate

857876-30-3sc-364541
sc-364541A
5 mg
10 mg
$255.00
$480.00
(0)

Motesanib Diphosphate functions as a potent acid halide, characterized by its ability to form stable complexes with metal catalysts, enhancing reaction efficiency. Its unique electronic structure facilitates selective nucleophilic attack, leading to distinct reaction pathways. The compound's solubility profile allows for varied reactivity in different solvent systems, influencing kinetic parameters and product distribution. This versatility makes it an intriguing subject for further exploration in synthetic methodologies.

PF 477736

952021-60-2sc-362781
sc-362781A
5 mg
25 mg
$113.00
$423.00
(1)

PF 477736 acts as a notable acid halide, exhibiting a propensity for rapid acylation reactions due to its electrophilic nature. Its unique steric and electronic properties enable it to engage in specific interactions with nucleophiles, promoting regioselectivity in synthetic pathways. The compound's reactivity is influenced by solvent polarity, which modulates its kinetic behavior and product formation, making it a compelling candidate for studying reaction dynamics in organic synthesis.

4,4′-Bis(4-aminophenoxy)biphenyl

13080-85-8sc-267771
5 g
$100.00
(0)

4,4'-Bis(4-aminophenoxy)biphenyl serves as a versatile acid halide, characterized by its ability to form stable intermediates through hydrogen bonding interactions. This compound demonstrates a unique capacity for facilitating nucleophilic substitutions, driven by its electron-rich aromatic system. The presence of multiple functional groups enhances its reactivity, allowing for diverse synthetic applications. Additionally, its solubility in various solvents influences its reactivity profile, making it an intriguing subject for mechanistic studies in organic chemistry.

AP 24534

943319-70-8sc-362710
sc-362710A
10 mg
50 mg
$172.00
$964.00
2
(1)

AP 24534 (Ponatinib) can inhibit multiple tyrosine kinases, including RET, disrupting its downstream effects.

VEGFR Tyrosine Kinase Inhibitor V

861874-34-2 anhydroussc-356190
5 mg
$240.00
(0)

VEGFR Tyrosine Kinase Inhibitor V exhibits distinctive reactivity as a Ret, showcasing a propensity for selective binding to specific tyrosine residues. Its unique structural features enable it to modulate signaling pathways effectively, influencing cellular responses. The compound's kinetic behavior reveals a rapid association with target proteins, while its conformational flexibility allows for adaptive interactions. This dynamic nature makes it a compelling candidate for exploring intricate biochemical mechanisms.

Sunitinib, Free Base

557795-19-4sc-396319
sc-396319A
500 mg
5 g
$150.00
$920.00
5
(0)

Sunitinib, Free Base, demonstrates remarkable characteristics as a Ret, characterized by its ability to form stable complexes with key protein targets. Its unique molecular architecture facilitates specific interactions with hydrophobic pockets, enhancing binding affinity. The compound exhibits a notable rate of dissociation, allowing for transient yet impactful modulation of cellular pathways. Additionally, its solubility profile supports diverse experimental conditions, making it a versatile tool for studying protein dynamics.

Regorafenib

755037-03-7sc-477163
sc-477163A
25 mg
50 mg
$320.00
$430.00
3
(0)

Regorafenib is a kinase inhibitor with activity against RET, leading to suppression of its downstream signaling.