RDH2 Inhibitors
RDH2 inhibitors are a class of chemicals that can inhibit the function of the RDH2 protein. RDH2, also known as retinol dehydrogenase 2, is an enzyme involved in the oxidation of retinol to retinal, an essential step in the metabolism of vitamin A. The inhibitors of RDH2 can act directly on the protein or indirectly by interfering with its enzymatic activity or substrate availability. Some of the direct inhibitors include citral and Quercetin, which can directly bind to RDH2 and disrupt its catalytic function, leading to the inhibitionof retinol oxidation. Other inhibitors such as 4-Hydroxyphenylretinamide, Ethanol, and Retinoic Acid, all trans can compete with retinol for binding to RDH2, reducing its availability for oxidation.
Indirect inhibitors of RDH2 include compounds like Fomepizole and Tranylcypromine, which inhibit enzymes involved in the conversion of retinol to retinal, thereby reducing the substrate availability for RDH2. NADPH depletion, caused by chemicals that inhibit NADPH-generating enzymes, can also indirectly inhibit RDH2 by disrupting the cofactor required for its enzymatic activity. Overall, RDH2 inhibitors can interfere with the normal function of RDH2 by directly binding to the protein, competing with retinol for binding, or indirectly affecting its enzymatic activity or substrate availability. These inhibitors provide valuable tools for studying the role of RDH2 in retinol metabolism.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
4-Hydroxyphenylretinamide is a synthetic retinoid that can potentially inhibit RDH2 by competing with retinol for binding and reducing its availability for RDH2-mediated oxidation. This can lead to a decrease in the enzymatic activity of RDH2. | ||||||
Fomepizole | 7554-65-6 | sc-252838 | 1 g | $75.00 | 1 | |
Fomepizole is a specific inhibitor of alcohol dehydrogenase (ADH), an enzyme that can convert retinol to retinal. By inhibiting ADH, Fomepizole can indirectly inhibit the conversion of retinol to retinal, reducing the substrate availability for RDH2. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral is a natural compound found in essential oils that can potentially inhibit RDH2 by interfering with its enzymatic activity. It can directly bind to RDH2 and disrupt its catalytic function, leading to inhibition of retinol oxidation. | ||||||
Tranylcypromine | 13492-01-8 | sc-200572 sc-200572A | 1 g 5 g | $175.00 $599.00 | 5 | |
Tranylcypromine is an irreversible inhibitor of monoamine oxidase (MAO), an enzyme that can oxidize retinol to retinal. By inhibiting MAO, Tranylcypromine can indirectly inhibit the conversion of retinol to retinal, reducing the substrate availability for RDH2. | ||||||
Acetaminophen | 103-90-2 | sc-203425 sc-203425A sc-203425B | 5 g 100 g 500 g | $41.00 $61.00 $194.00 | 11 | |
Acetaminophen can potentially inhibit RDH2 by competing with retinol for binding and reducing its availability for RDH2-mediated oxidation. This can lead to a decrease in the enzymatic activity of RDH2. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a natural flavonoid that can potentially inhibit RDH2 by interfering with its enzymatic activity. It can directly bind to RDH2 and disrupt its catalytic function, leading to inhibition of retinol oxidation. | ||||||
6-Azauridine | 54-25-1 | sc-221082B sc-221082 sc-221082C sc-221082A | 500 mg 1 g 2 g 5 g | $97.00 $159.00 $295.00 $679.00 | ||
6-Azauridine is a nucleoside analog that can potentially inhibit RDH2 by interfering with its enzymatic activity. It can directly bind to RDH2 and disrupt its catalytic function, leading to inhibition of retinol oxidation. | ||||||