Prolyl Hydroxylase Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Deferoxamine mesylate | 138-14-7 | sc-203331 sc-203331A sc-203331B sc-203331C sc-203331D | 1 g 5 g 10 g 50 g 100 g | $255.00 $1060.00 $2923.00 $4392.00 $8333.00 | 19 | |
Deferoxamine mesylate acts as a prolyl hydroxylase inhibitor, engaging in specific interactions with the enzyme's active site. Its unique chelating properties allow it to stabilize iron in a way that alters the enzyme's conformation, impacting the hydroxylation of proline residues in hypoxia-inducible factors. This modulation affects downstream signaling pathways, influencing cellular responses to oxygen levels. The compound's solubility characteristics enhance its bioavailability, facilitating its interaction with target proteins. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $84.00 $301.00 $374.00 $779.00 | 25 | |
Dimethyloxaloylglycine (DMOG) functions as a prolyl hydroxylase inhibitor by mimicking the natural substrate, thereby competing for the enzyme's active site. Its structural features allow for specific hydrogen bonding and hydrophobic interactions, which stabilize the enzyme-substrate complex. This interference disrupts the hydroxylation process of proline residues, leading to altered stability of hypoxia-inducible factors. Additionally, DMOG's unique molecular configuration influences its reactivity and interaction kinetics, enhancing its efficacy in modulating cellular oxygen sensing pathways. | ||||||
IOX2 | 931398-72-0 | sc-482692 sc-482692A sc-482692B | 5 mg 25 mg 100 mg | $131.00 $566.00 $1613.00 | ||
IOX2 is a selective prolyl hydroxylase inhibitor that modulates hypoxia-inducible factor (HIF) pathways by stabilizing HIF-α subunits. Its unique structure allows for specific interactions with the enzyme's active site, influencing reaction kinetics and substrate affinity. The compound's ability to alter hydroxylation patterns can lead to significant changes in cellular responses to oxygen levels, showcasing its role in regulating metabolic pathways and gene expression. | ||||||