prefoldin 2 Inhibitors
Prefoldin 2 Inhibitors are a class of chemicals that target Prefoldin 2, a molecular chaperone protein involved in protein folding and assembly processes within cells. These inhibitors can interfere with the function of Prefoldin 2, leading to the inhibition of its role in proper protein folding. Direct inhibitors of Prefoldin 2, such as geldanamycin and its derivatives (17-AAG and 17-DMAG, Hydrochloride Salt), target heat shock protein 90 (Hsp90), which is involved in the stabilization and folding of Prefoldin 2. These inhibitors bind to the ATP-binding site of Hsp90, disrupting its chaperone function and destabilizing Prefoldin 2. This results in the degradation of Prefoldin 2 and the subsequent inhibition of its activity. Indirect inhibitors of Prefoldin 2, such as quercetin, (-)-Epigallocatechin Gallate, apigenin, curcumin, and myricetin, interfere with the interaction between Prefoldin 2 and its client proteins. These inhibitors disrupt the binding between Prefoldin 2 and its substrates, preventing proper folding and assembly of the client proteins.
Another indirect inhibitor, radicicol, also targets Hsp90. It binds to Hsp90 and inhibits its chaperone function, leading to the destabilization of Prefoldin 2 and subsequent inhibition of its activity. Withaferin A and withanolide D, both indirect inhibitors, target the chaperone function of Hsp90. They bind to Hsp90 and disrupt its interaction with Prefoldin 2, resulting in the inhibition of Prefoldin 2-mediated protein folding. Celastrol, Celastrus scandens, another indirect inhibitor, disrupts the interaction between Hsp90 and Prefoldin 2, leading to the destabilization and degradation of Prefoldin 2, resulting in its inhibition. In summary, Prefoldin 2 Inhibitors are a diverse class of chemicals that can directly or indirectly inhibit the function of Prefoldin 2. These inhibitors target either Prefoldin 2 itself or the chaperone function of Hsp90, leading to the destabilization and degradation of Prefoldin 2 and the subsequent inhibition of its role in protein folding and assembly processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin inhibits Prefoldin 2 indirectly by targeting heat shock protein 90 (Hsp90), which is involved in the folding and stabilization of Prefoldin 2. Inhibition of Hsp90 leads to the degradation of Prefoldin 2, resulting in its inhibition. | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $90.00 $326.00 | 13 | |
Radicicol is another inhibitor of Prefoldin 2 that acts by targeting Hsp90. It binds to the ATP-binding site of Hsp90, inhibiting its chaperone function and destabilizing Prefoldin 2, thereby inhibiting its activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin inhibits Prefoldin 2 by interfering with its interaction with other proteins. It disrupts the binding between Prefoldin 2 and its client proteins, preventing proper folding and assembly of the client proteins. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
(-)-Epigallocatechin Gallate is a polyphenol compound found in green tea that inhibits Prefoldin 2 by disrupting its interaction with client proteins. It interferes with the binding between Prefoldin 2 and its substrates, leading to the inhibition of proper protein folding. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Withaferin A inhibits Prefoldin 2 by targeting the chaperone function of Hsp90. It binds to Hsp90 and disrupts its interaction with Prefoldin 2, resulting in the inhibition of Prefoldin 2-mediated protein folding. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG is a derivative of geldanamycin that inhibits Prefoldin 2 by targeting Hsp90. It binds to the ATP-binding site of Hsp90, leading to the degradation of Prefoldin 2 and the subsequent inhibition of its chaperone activity. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Celastrol, Celastrus scandens inhibits Prefoldin 2 indirectly by targeting Hsp90. It disrupts the interaction between Hsp90 and Prefoldin 2, leading to the destabilization and degradation of Prefoldin 2, resulting in its inhibition. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin inhibits Prefoldin 2 by interfering with its interaction with client proteins. It disrupts the binding between Prefoldin 2 and its substrates, preventing proper folding and assembly of the client proteins. | ||||||
Myricetin | 529-44-2 | sc-203147 sc-203147A sc-203147B sc-203147C sc-203147D | 25 mg 100 mg 1 g 25 g 100 g | $95.00 $184.00 $255.00 $500.00 $1002.00 | 3 | |
Myricetin inhibits Prefoldin 2 by interfering with its interaction with client proteins. It disrupts the binding between Prefoldin 2 and its substrates, preventing proper folding and assembly of the client proteins. | ||||||
17-DMAG, Hydrochloride Salt | 467214-21-7 | sc-396751 | 25 mg | $306.00 | ||
17-DMAG, Hydrochloride Salt is a derivative of geldanamycin that inhibits Prefoldin 2 by targeting Hsp90. It binds to the ATP-binding site of Hsp90, leading to the degradation of Prefoldin 2 and the subsequent inhibition of its chaperone activity. | ||||||