PP2A-B56-γ Inhibitors
The chemical class known as PP2A-B56-γ Inhibitors comprises a group of compounds that can either directly inhibit PP2A-B56-γ or indirectly inhibit its activity through various signaling pathways and mechanisms. PP2A-B56-γ is a regulatory subunit of PP2A that plays a critical role in dephosphorylating specific substrates to regulate various cellular processes. Compounds like Cantharidin, LB-100 and LB-102 directly inhibit PP2A, including PP2A-B56-γ, leading to the accumulation of phosphorylated substrates and potential inhibition of downstream pathways. Calyculin A, Okadaic Acid, and Microcystin-LR directly inhibit PP2A-B56-γ, preventing its dephosphorylation activity on substrates, leading to increased phosphorylation.
Endothall and Perphenazine inhibit PP2A, including PP2A-B56-γ, leading to increased phosphorylation of target proteins and potential pathway inhibition. Endosulfan directly inhibits PP2A-B56-γ, preventing its dephosphorylation activity on substrates, leading to increased phosphorylation. NMDA receptor activation can indirectly activate PP2A-B56-γ by increasing intracellular Ca2+ levels, which can activate Ca2+/calmodulin-dependent PP2A.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Cantharidin inhibits PP2A-B56-γ directly, preventing its dephosphorylation activity on substrates, leading to increased phosphorylation. | ||||||
LB-100 | 1632032-53-1 | sc-507368 | 10 mg | $330.00 | ||
LB-100 is a potent PP2A inhibitor, including PP2A-B56-γ, leading to the accumulation of phosphorylated substrates and downstream pathway inhibition. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits PP2A-B56-γ directly, leading to the accumulation of phosphorylated substrates and potential pathway activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid inhibits PP2A-B56-γ directly, preventing its dephosphorylation activity on substrates, leading to increased phosphorylation. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $49.00 $203.00 | 1 | |
Endothall inhibits PP2A, including PP2A-B56-γ, leading to increased phosphorylation of target proteins and potential pathway activation. | ||||||
Perphenazine | 58-39-9 | sc-208161 | 100 mg | $190.00 | ||
Perphenazine inhibits PP2A, including PP2A-B56-γ, leading to increased phosphorylation of target proteins and potential pathway inhibition. | ||||||