Polyethylene Glycol Activators
Polyethylene Glycol Activators encompass a range of chemical compounds that enhance its functional activity, particularly in drug delivery applications. Forskolin, by raising intracellular cAMP levels, indirectly enhances the bioavailability and stability of Polyethylene Glycol in aqueous solutions, a critical factor for its efficacy as a drug delivery vehicle. Similarly, Dimethyl Sulfoxide (DMSO) and Ethanol elevate the solubility of Polyethylene Glycol, particularly in organic solvents, which is vital for formulating drugs where Polyethylene Glycol is used to improve solubility and stability. Glycerol and Propylene Glycol act as plasticizers and co-solvents, respectively, augmenting the flexibility and solubility properties of Polyethylene Glycol, thereby facilitating its conjugation with molecules and enhancing its role as an excipient. The functional activity of Polyethylene Glycol is further augmented by Sodium Chloride's modulation of its phase behavior in solutions, which can enhance micelle formation for drug delivery, and by Polysorbate 80, which acts as a surfactant to improve dispersion in solution.
Additionally, the utility of Polyethylene Glycol in drug delivery systems is significantly enhanced by the formation of stable liposomes when combined with PEGylated Lipids, which promotes targeted delivery. EDTA's chelation of metal ions stabilizes Polyethylene Glycol solutions by preventing degradation, thus maintaining its functional integrity. The presence of Trehalose enhances the protective effect of Polyethylene Glycol in pharmaceutical formulations by stabilizing sensitive biological molecules. N,N-Dimethylformamide (DMF) increases the solubility of Polyethylene Glycol in organic phases, which is beneficial for drug delivery systems that require enhanced solubilization of active pharmaceutical ingredients.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates intracellular cAMP levels, which can enhance Polyethylene Glycol by promoting its solubility and stability in aqueous solutions, thereby increasing its bioavailability and functional activity as a drug delivery vehicle. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO can enhance the solubility of Polyethylene Glycol in organic solvents, facilitating its application in drug formulations where solubility is critical for Polyethylene Glycol functional activity. | ||||||
Glycerol | 56-81-5 | sc-29095A sc-29095 | 100 ml 1 L | $56.00 $153.00 | 12 | |
Glycerol's role as a plasticizer can increase the flexibility of Polyethylene Glycol chains, potentially enhancing its ability to form stable conjugations with therapeutic molecules. | ||||||
Sodium Chloride | 7647-14-5 | sc-203274 sc-203274A sc-203274B sc-203274C | 500 g 2 kg 5 kg 10 kg | $19.00 $30.00 $60.00 $110.00 | 15 | |
Sodium Chloride can influence the phase behavior of Polyethylene Glycol in aqueous solutions, potentially enhancing its ability to form micelles for drug delivery. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $30.00 $167.00 $260.00 | 2 | |
Trehalose can stabilize proteins and other biological molecules, which, when combined with Polyethylene Glycol, can enhance its protective effect in pharmaceutical formulations. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $50.00 $110.00 $145.00 $248.00 $598.00 | 1 | |
Citric Acid can act as a buffering agent, maintaining pH stability in formulations containing Polyethylene Glycol, thereby enhancing its functional efficacy as an excipient. | ||||||