POLR3D Activators

RNA polymerase III subunit D (POLR3D) is an integral component of RNA polymerase III, the enzyme complex responsible for the synthesis of small, non-coding RNAs in eukaryotic cells. The gene that encodes for this protein is also referred to as POLR3D. POLR3D serves as one of the 17 subunits that constitute the RNA polymerase III complex, which is tasked with transcribing genes such as 5S rRNA, tRNA, and other small RNAs that play vital roles in the regulation of gene expression and the maintenance of cellular function.

POLR3D specifically is part of the core assembly of RNA polymerase III, contributing to the structural and functional stability of the complex. Its interactions within the polymerase are essential for the accurate initiation and elongation phases of transcription. The subunit is also believed to participate in the intricate processes that govern the recognition of promoter regions on DNA, ensuring that RNA polymerase III reliably targets the correct genes for transcription.Mutations in the POLR3D gene have been linked to rare and severe disorders, reflecting the critical nature of its role in cellular biology. These disorders are often characterized by defects in brain development and function, demonstrating the importance of POLR3D in the central nervous system. Additionally, given the fundamental necessity of the small RNAs synthesized by RNA polymerase III in various cellular processes, including protein synthesis and RNA splicing, POLR3D's involvement in health and disease is broad and significant.