Pmel17 Activators
Pmel17 Activators belong to a class of chemical compounds designed to modulate the activity of Pmel17, also known as gp100 or PMEL (premelanosome protein). Pmel17 is a melanocyte-specific protein that plays a pivotal role in the process of melanin biosynthesis and its subsequent packaging into melanosomes, specialized organelles found in melanocytes. Melanin is a pigment responsible for the coloration of skin, hair, and eyes in vertebrates, and it provides protection against the harmful effects of ultraviolet (UV) radiation from the sun. Pmel17 is primarily involved in the formation of melanin fibrils, which serve as a scaffold for melanin deposition and contribute to the structural integrity of melanosomes. Pmel17 Activators are synthesized with the intent of selectively interacting with Pmel17, influencing its conformation, melanin-binding properties, or its role in melanin fibrillogenesis, although the specific mechanisms can vary among different compounds within this chemical class.
The activation or modulation of Pmel17 by these compounds can impact melanin production and pigment distribution in melanocytes. Melanin biosynthesis is a complex and highly regulated process, with Pmel17 being a critical component in the formation of melanosomes. Pmel17 undergoes proteolytic processing to generate fragments that interact with melanin intermediates, leading to the deposition of melanin within melanosomes. Pmel17 Activators serve as valuable research tools for scientists studying pigmentation, melanosome biology, and the molecular mechanisms underlying melanin synthesis. They allow researchers to investigate how modulating Pmel17 activity may influence melanosome structure, melanin production, and the pigmentation of skin, hair, and eyes. However, it's important to note that the specific mechanisms and outcomes of Pmel17 activation may vary depending on the context and the particular compound used within this chemical class, given the complexity of melanin synthesis and its role in diverse biological processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Melanocyte stimulating hormone | 581-05-5 | sc-364762 sc-364762A sc-364762B | 1 mg 5 mg 25 mg | $84.00 $210.00 $926.00 | ||
Alpha-MSH (Melanocyte-Stimulating Hormone) can increase the expression of Pmel17 by activating the MC1R receptor, leading to increased cAMP levels and downstream signaling that promotes melanogenesis. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, through the activation of adenylate cyclase, elevates intracellular cAMP levels, which in turn can stimulate the expression of Pmel17 as part of the melanogenic pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-specific phosphodiesterase inhibitor that increases cAMP levels in cells, potentially enhancing Pmel17 expression by mimicking melanocyte-stimulating conditions. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol may modulate Pmel17 expression through estrogen receptor-mediated signaling pathways, influencing melanocyte biology and pigmentation processes. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline, a phosphodiesterase inhibitor, can increase cAMP levels in cells, potentially influencing Pmel17 expression through pathways related to melanin production. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin may affect Pmel17 expression by interacting with cellular receptors and signaling pathways that are involved in melanocyte biology and pigment production. | ||||||