Date published: 2025-10-15

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PKA Substrates

Santa Cruz Biotechnology now offers a broad range of PKA Substrates for use in various applications. PKA Substrates are crucial tools for studying the activity and specificity of protein kinase A (PKA), an enzyme that plays a pivotal role in regulating a wide array of cellular processes, including metabolism, gene expression, cell cycle progression, and apoptosis. By providing specific substrates for PKA, researchers can measure its kinase activity and investigate the phosphorylation events mediated by this enzyme, which are essential for understanding its regulatory functions. In scientific research, PKA Substrates are utilized to explore the downstream signaling pathways activated by cyclic AMP (cAMP)-dependent PKA and to delineate the role of PKA in various physiological contexts. Researchers employ these substrates to study how PKA-mediated phosphorylation affects the function of target proteins and how these modifications influence cellular responses to external stimuli. Additionally, PKA Substrates are valuable in high-throughput screening assays for identifying potential inhibitors or activators of PKA, facilitating the discovery of new regulatory mechanisms and pathways. The use of PKA Substrates supports the development of experimental models that help explain the complex signaling networks controlled by PKA and their broader implications in cellular function and adaptation. View detailed information on our available PKA Substrates by clicking on the product name.

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Items 21 to 23 of 23 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Op18 (Ser 63)

sc-24524
0.5 mg/0.1 ml
$95.00
(0)

Op18 (Ser 63) serves as a pivotal substrate for protein kinase A (PKA), where its phosphorylation at the serine residue induces conformational changes that modulate enzyme activity. This modification enhances the binding affinity for specific regulatory proteins, thereby influencing downstream signaling cascades. The unique reaction kinetics associated with Op18 phosphorylation allow for precise temporal control in cellular responses, highlighting its role in dynamic regulatory networks.

WT (Ser 393)

sc-24525
0.5 mg/0.1 ml
$95.00
(0)

WT (Ser 393) acts as a critical modulator in the PKA signaling pathway, where its phosphorylation alters the structural dynamics of the protein. This modification facilitates unique electrostatic interactions that stabilize enzyme-substrate complexes, enhancing catalytic efficiency. The distinct reaction kinetics of WT (Ser 393) phosphorylation enable rapid signal transduction, allowing for fine-tuned cellular responses and integration into complex regulatory mechanisms.

WT (Ser 363)

sc-24526
0.5 mg/0.1 ml
$95.00
(0)

WT (Ser 363) serves as a pivotal regulator within the PKA signaling cascade, where its phosphorylation induces conformational changes that impact protein interactions. This modification promotes specific hydrogen bonding and hydrophobic interactions, which are essential for substrate recognition. The unique reaction kinetics associated with WT (Ser 363) phosphorylation allow for swift modulation of downstream signaling events, contributing to the precision of cellular regulatory networks.