PEG Linkers

Acid-PEG9-NHS ester is a versatile PEG linker distinguished by its extended hydrophilic chain and reactive NHS ester group. This structure promotes rapid and selective conjugation with amines, enabling efficient bioconjugation processes. The nine-unit PEG segment enhances solubility and biocompatibility, while the acid functionality allows for fine-tuning of reaction kinetics. Its design minimizes steric hindrance, ensuring optimal molecular interactions and stability in various applications.

Acid-PEG13-NHS ester features a longer polyethylene glycol (PEG) chain, enhancing its solubility and flexibility in diverse environments. The NHS ester moiety facilitates efficient coupling with nucleophiles, promoting rapid reaction kinetics. This linker’s unique structure allows for precise control over conjugation efficiency, while its acid group can modulate pH sensitivity, influencing reactivity. The extended PEG segment also reduces non-specific interactions, ensuring targeted applications.

Acid-PEG24-NHS ester is characterized by its extended polyethylene glycol (PEG) chain, which significantly increases hydrophilicity and steric hindrance, minimizing aggregation in solution. The NHS ester group enables selective and efficient conjugation with amines, promoting rapid reaction rates. Its unique structure allows for fine-tuning of linker length, impacting molecular mobility and interaction dynamics. Additionally, the acid functionality can influence solubility and reactivity under varying pH conditions, enhancing versatility in diverse applications.

Mal-PEG4-NHS ester features a four-unit polyethylene glycol (PEG) segment that enhances solubility and flexibility, facilitating effective molecular interactions. The NHS ester moiety provides a reactive site for amine coupling, promoting swift and specific conjugation. This compound exhibits unique reactivity profiles, allowing for controlled modification of biomolecules. Its hydrophilic nature aids in maintaining stability in aqueous environments, while the linker length can be adjusted to optimize spatial arrangement and functional accessibility.

Mal-PEG6-NHS ester is characterized by a six-unit polyethylene glycol (PEG) chain that imparts significant hydrophilicity and steric hindrance, enhancing the solubility of conjugated entities. The NHS ester group enables efficient amine coupling, facilitating rapid and selective reactions. This compound's extended linker length allows for greater spatial separation between functional groups, which can improve the overall stability and functionality of the resulting conjugates in various environments.

m-PEG3-NHS carbonate features a three-unit polyethylene glycol (PEG) chain that enhances solubility while providing a balance of hydrophilicity and hydrophobicity. The carbonate moiety allows for versatile reactivity, enabling selective coupling with nucleophiles. Its unique structure promotes efficient molecular interactions, facilitating the formation of stable conjugates. The linker’s moderate length aids in optimizing spatial arrangement, which can influence reaction kinetics and enhance the performance of linked entities.

Mal-PEG4-acid is a versatile PEG linker characterized by its four-unit polyethylene glycol chain, which imparts significant flexibility and solubility. The carboxylic acid functional group enables efficient conjugation with amines and other nucleophiles, promoting rapid reaction kinetics. Its unique structure fosters strong molecular interactions, enhancing the stability of conjugates. The linker’s extended length allows for optimal spatial orientation, influencing the dynamics of molecular assemblies.

Mal-PEG6-acid is a specialized PEG linker featuring a six-unit polyethylene glycol chain that enhances hydrophilicity and solubility in various environments. The presence of a carboxylic acid group facilitates robust interactions with amines, enabling swift conjugation reactions. Its elongated structure promotes effective steric hindrance, which can modulate the behavior of linked molecules. This linker also exhibits unique conformational flexibility, allowing for tailored spatial arrangements in complex systems.

Mal-PEG3-alcohol is a versatile PEG linker characterized by a three-unit polyethylene glycol chain that enhances solubility and biocompatibility. The terminal alcohol group enables hydrogen bonding, facilitating specific interactions with various substrates. Its shorter chain length allows for rapid diffusion in biological environments, while maintaining a balance between flexibility and rigidity. This property aids in optimizing molecular interactions and improving the stability of conjugated entities.

3,4-Dibromo-Mal-PEG2-Boc-amine is a specialized PEG linker featuring a two-unit polyethylene glycol chain, which promotes enhanced solubility and functional versatility. The presence of dibromo groups introduces unique reactivity, allowing for selective coupling with amines and thiols. This compound exhibits favorable reaction kinetics, enabling efficient conjugation processes. Its Boc protection enhances stability, while the malonate moiety facilitates diverse chemical transformations, making it a valuable tool for complex molecular assembly.