OTTMUSG00000018259 Activators
Alpha-defensin 5-like precursor, referred to as Defa37, represents a critical component of the innate immune system, specifically within the spectrum of antimicrobial peptides known as defensins. These peptides are paramount in the first line of defense against a broad range of pathogens, including bacteria, fungi, and viruses. The structure of alpha-defensins is characterized by a conserved framework that supports their ability to permeabilize microbial membranes, a mechanism fundamental to their antimicrobial action. The activation and function of alpha-defensins, including Defa37, are intricately linked to their proper folding, stability, and localization within host tissues, particularly mucosal surfaces where they serve as key elements of the host's protective barrier.
The general mechanisms by which the functional activation of alpha-defensin 5-like precursor could be facilitated involve a multifaceted approach targeting the stabilization of peptide structure, modulation of cellular signaling pathways that regulate defensin activity, and enhancement of the intracellular environment conducive to defensin action. This includes the potential for certain chemicals to stabilize the defensin precursors, ensuring their proper folding and spatial configuration necessary for antimicrobial activity. Additionally, the modulation of signaling pathways that govern the expression, processing, and secretion of defensins can amplify their antimicrobial functions. Given the broad range of pathogens targeted by defensins, the activation of these peptides is a critical aspect of the innate immune response, ensuring a rapid and effective defense mechanism against microbial invasion. The theoretical activation of Defa37 through indirect means, as outlined in the selection of chemicals, underscores the complexity of immune regulation and the potential for targeted interventions to enhance the natural antimicrobial defenses of the host.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions are known to stabilize protein structures and can enhance the antimicrobial activity of defensins by promoting proper folding and stability of alpha-defensin 5-like precursor, thereby enhancing its functional activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate, a short-chain fatty acid, can modulate intracellular signaling pathways leading to enhanced antimicrobial peptide activity. It may enhance the functional activity of alpha-defensin 5-like precursor by facilitating a cellular environment conducive to its activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid influences cell differentiation and proliferation. It may indirectly activate alpha-defensin 5-like precursor by promoting the differentiation of epithelial cells, which are known to produce defensins, thereby possibly increasing the functional activity of these antimicrobial peptides. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol modulates immune responses and has been shown to induce the expression of antimicrobial peptides. It may indirectly activate alpha-defensin 5-like precursor by upregulating cellular pathways that enhance the antimicrobial peptide's functional activation and stability. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can activate the Wnt/β-catenin pathway, which is implicated in the regulation of several genes involved in immunity. By activating this pathway, lithium chloride could contribute to the functional activation of alpha-defensin 5-like precursor by promoting cellular mechanisms that enhance its antimicrobial efficacy. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to modulate several signaling pathways, including NF-κB, which is involved in the immune response and the expression of antimicrobial peptides. Curcumin could thus indirectly activate alpha-defensin 5-like precursor by modulating pathways that enhance its antimicrobial functions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol influences various signaling pathways, including Sirtuin 1 (SIRT1) activation, which plays a role in the regulation of immune responses. Through its action on SIRT1 and related pathways, resveratrol could contribute to the functional activation of alpha-defensin 5-like precursor by enhancing the cellular processes that regulate antimicrobial peptide activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, modulates signaling pathways that are implicated in inflammatory responses and might influence the activity of antimicrobial peptides. It could indirectly activate alpha-defensin 5-like precursor by modulating cellular signaling pathways that enhance the antimicrobial efficacy of defensins. | ||||||
Ferulic acid | 1135-24-6 | sc-204753 sc-204753A sc-204753B sc-204753C sc-204753D | 5 g 25 g 100 g 500 g 1 kg | $42.00 $62.00 $153.00 $552.00 $988.00 | 10 | |
Ferulic acid, an antioxidant, can modulate cellular redox states and signaling pathways that influence the activity of antimicrobial peptides. By affecting these pathways, ferulic acid might enhance the functional activation of alpha-defensin 5-like precursor, contributing to its antimicrobial activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG), a major component of green tea, has been shown to modulate several signaling pathways involved in immune responses. EGCG could indirectly activate alpha-defensin 5-like precursor by influencing pathways that enhance the stability and activity of antimicrobial peptides. | ||||||