OTTMUSG00000016611 Activators

KRAB box and zinc finger, C2H2 type domain containing protein is a versatile transcriptional regulator involved in gene expression control. It possesses zinc finger domains that enable specific DNA binding and transcriptional modulation. This protein plays a crucial role in the epigenetic regulation of target genes, acting as a transcriptional repressor or activator depending on its interactions with other molecules. Activation of KRAB box and zinc finger protein primarily occurs through epigenetic mechanisms. The chemicals listed in the table above serve as activators by inhibiting histone deacetylases, promoting histone hyperacetylation, and subsequently leading to the epigenetic activation of this protein. Additionally, some chemicals indirectly activate this protein by modulating various signaling pathways, such as retinoic acid receptor signaling or SIRT1 pathway, which enhance the expression and functional activation of KRAB box and zinc finger, C2H2 type domain containing protein.

In conclusion, the functional activation of KRAB box and zinc finger, C2H2 type domain containing protein is essential for its role in gene regulation and transcriptional control. The chemicals mentioned in the table provide valuable tools for researchers to study and manipulate the functions of this protein, particularly in the context of epigenetic modifications and gene expression regulation.