OTTMUSG00000011290 Activators

Interferon zeta-like precursor, encoded by the gene Gm13289, plays a crucial role in the immune response, particularly in the interferon signaling pathways. Interferons are a group of signaling proteins made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and tumor cells. They are key components of the innate immune system and function by signaling the presence of pathogens to other cells and activating immune cells. The specific function of interferon zeta-like precursor in these processes is not thoroughly characterized, but its role within the broad interferon signaling network is significant.

The activation of interferon zeta-like precursor, like other interferon types, involves complex signaling pathways. Typically, interferon activation is initiated by the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs). This recognition triggers a signaling cascade that leads to the activation of transcription factors such as NF-κB and interferon regulatory factors (IRFs), which then promote the transcription of interferon genes. Once synthesized, interferons bind to specific receptors on the surface of cells, activating the JAK-STAT signaling pathway. This pathway leads to the transcription of various interferon-stimulated genes (ISGs) that confer antiviral states to the cells. Given the complexity of these pathways, the activation of interferon zeta-like precursor is likely to involve a similar cascade of molecular events.