OR8K1 Activators
OR8K1, an olfactory receptor protein, engage in a series of molecular interactions that culminate in the activation of this receptor. Isoproterenol, a beta-adrenergic agonist, binds to its target receptors on olfactory sensory neurons and stimulates adenylyl cyclase, an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP). The resulting increase in cAMP levels within the cells subsequently activates OR8K1, as the receptor is part of the cAMP-dependent signaling pathway. Similarly, Forskolin, by directly activating adenylyl cyclase, bypasses receptor-mediated steps and leads to an elevation of cAMP, which then activates OR8K1. These processes initiate a cascade of intracellular events that are integral to the function of olfactory sensory neurons.
Compounds like IBMX, theophylline, caffeine, rolipram, sildenafil, vardenafil, tadalafil, zaprinast, papaverine, and vinpocetine exert their effects by modulating the concentration of intracellular cAMP, albeit through a different mechanism. These chemicals are inhibitors of various phosphodiesterases (PDEs), which are enzymes responsible for breaking down cAMP. By inhibiting PDEs, these molecules prevent the degradation of cAMP, leading to sustained higher levels of this signaling molecule within the olfactory sensory neuron. Elevated cAMP levels, in turn, activate OR8K1, as the receptor is responsive to the cAMP present in the cell. This activation is an essential step in the signal transduction process that allows the olfactory system to detect and respond to specific chemical stimuli. Through these chemical interactions, OR8K1 becomes an integral player in the complex network of molecular signals that underpin the sense of smell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
As OR8K1 is an olfactory receptor, isoproterenol, a beta-adrenergic agonist, activates adenylyl cyclase, leading to increased cAMP levels in olfactory sensory neurons, which in turn can activate OR8K1 through cAMP-dependent signaling pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, thereby increasing cAMP concentration in olfactory sensory neurons. Elevated cAMP can activate OR8K1 as part of the signal transduction mechanism inherent to these sensory neurons. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
3-Isobutyl-1-methylxanthine (IBMX) is a nonspecific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP. By maintaining high levels of cAMP, IBMX would support the continuous activation of OR8K1 through cAMP-dependent pathways in olfactory neurons. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline is a phosphodiesterase inhibitor leading to an increase in cAMP by preventing its breakdown. Higher cAMP levels would activate OR8K1 by enhancing the cAMP-dependent signal transduction cascade in olfactory cells. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Similar to theophylline, caffeine is also a phosphodiesterase inhibitor. It increases intracellular cAMP levels, which can lead to the activation of OR8K1 through the cAMP signaling pathway in olfactory receptor neurons. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which leads to an increase in cAMP levels within cells. This increase can activate OR8K1 in olfactory sensory neurons as part of the cAMP signaling pathway. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $516.00 $720.00 $16326.00 | 7 | |
Vardenafil, another PDE5 inhibitor, raises cAMP and cGMP levels by preventing their degradation, which can indirectly activate OR8K1 in olfactory pathways through elevated cAMP/cGMP signaling. | ||||||
Tadalafil | 171596-29-5 | sc-208412 | 50 mg | $176.00 | 13 | |
Tadalafil is a PDE5 inhibitor that, by elevating cAMP and cGMP levels due to inhibition of their hydrolysis, can indirectly activate OR8K1 in olfactory receptor neurons through the cAMP signaling cascade. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast is a selective inhibitor of PDE5, like the previous entries, it raises cAMP and cGMP levels, contributing to the activation of OR8K1 through the cAMP signaling pathway in olfactory neurons. | ||||||
Papaverine | 58-74-2 | sc-279951 sc-279951A sc-279951B | 10 mg 50 mg 100 mg | $153.00 $265.00 $459.00 | ||
Papaverine inhibits phosphodiesterases, leading to increased cAMP levels. This increase can activate OR8K1 in olfactory receptor neurons by enhancing the cAMP-mediated signaling pathway. | ||||||