OR5AP2 Activators
OR5AP2 span a diverse array of compounds that engage various signaling pathways to modulate the activity of this protein. Isoproterenol, epinephrine, and norepinephrine are catecholamines that can activate OR5AP2 by stimulating β-adrenergic receptors, leading to increased intracellular cAMP levels. The rise in cAMP facilitates the activation of protein kinase A (PKA), which subsequently can phosphorylate and influence the activity of proteins within the G protein-coupled receptor (GPCR) signaling pathways, including OR5AP2. Forskolin, by directly stimulating adenylyl cyclase, bypasses receptor activation and leads to an accumulation of cAMP, which further activates PKA and can modulate the activity of OR5AP2. Dopamine, acting through its specific GPCRs, also affects cAMP levels and is part of the broader signaling context that can activate OR5AP2.
In addition to these activators, other chemicals interact with different facets of the GPCR signaling mechanism to influence OR5AP2. Histamine, via H1 receptors, activates phospholipase C, leading to the production of secondary messengers that can modulate GPCR signaling pathways involving OR5AP2. Serotonin, through its receptors, can either increase cAMP or activate the phospholipase C pathway. Adenosine, by engaging with its G protein-coupled adenosine receptors, can either increase or decrease cAMP production, depending on the receptor subtype, affecting the activity of OR5AP2. Moreover, prostaglandin E2 (PGE2) interacts with E-prostanoid receptors that activate adenylate cyclase, leading to increased cAMP levels and subsequent activation of PKA, which can influence OR5AP2 activity. Acetylcholine, through muscarinic receptors, and nicotine, through nicotinic acetylcholine receptors, can indirectly influence the GPCR signaling pathways, thus affecting the activity of OR5AP2. Ibuprofen alters prostaglandin levels and therefore can influence GPCR signaling and the activation state of OR5AP2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a β-adrenergic agonist, can activate the OR5AP2 protein by stimulating the β-adrenergic receptors which leads to an increase in intracellular cyclic AMP (cAMP) levels. Elevated cAMP can enhance the G protein-coupled receptor (GPCR) mediated signaling pathways, which OR5AP2, being an olfactory receptor, is part of. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to and activates adrenergic receptors, which can result in increased cAMP production through adenylyl cyclase activation. The subsequent signaling cascade can activate proteins within the GPCR pathway, such as OR5AP2. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Norepinephrine acts on adrenergic receptors and can lead to increased cAMP levels, similar to epinephrine, thereby activating kinase pathways that can phosphorylate and activate GPCR pathway proteins including OR5AP2. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can bind to its GPCRs leading to changes in cAMP levels. This can influence the GPCR signaling network, possibly leading to the activation of OR5AP2 as part of this broader signaling context. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, through its action on H1 receptors, can activate phospholipase C, resulting in the production of diacylglycerol (DAG) and inositol triphosphate (IP3). This cascade can modulate GPCR signaling pathways that OR5AP2 is a part of. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
Serotonin activates its GPCRs, which can lead to an increase in cAMP production or activation of the phospholipase C pathway, both of which can influence the signaling pathways involving GPCR proteins like OR5AP2. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine interacts with its G protein-coupled adenosine receptors, which can lead to varied effects on cAMP production. Depending on the receptor subtype, this can result in the activation of the OR5AP2 protein within the GPCR signaling pathways. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $53.00 $88.00 | 6 | |
Ibuprofen, while primarily known as a nonsteroidal anti-inflammatory drug, can influence GPCR signaling by altering prostaglandin levels, which could lead to the indirect activation of OR5AP2 through GPCR-mediated pathways. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 binds to its G-protein coupled E-prostanoid receptors, which can lead to the activation of adenylate cyclase and subsequent increases in cAMP. This, in turn, could activate PKA and influence the activity of GPCR proteins, including OR5AP2. | ||||||