OR4A16 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamaldehyde is an agonist of the TRPA1 channel, which is co-expressed with olfactory receptors such as OR4A16 in olfactory sensory neurons. Activation of TRPA1 can lead to calcium influx, which indirectly reduces OR4A16 sensitivity by causing desensitization or adaptation of olfactory receptors. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol is a TRPM8 agonist, another channel expressed with olfactory receptors. TRPM8 activation by eugenol can alter the intracellular signaling pathways, leading to a decrease in the functional activity of OR4A16 by modulation of the calcium homeostasis within the olfactory sensory neurons. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin is a selective agonist of the TRPV1 channel. Co-activation of TRPV1 in the olfactory system can decrease OR4A16 activity through depolarization-induced desensitization, which affects the olfactory receptor neurons' ability to respond to subsequent stimuli. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
Menthol acts as an agonist of TRPM8 channels. The activation of these channels can lead to changes in the sensory neuron's membrane potential and a subsequent decrease in OR4A16 signaling due to the desensitization of the olfactory signal transduction machinery. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper ions can act as allosteric modulators of several receptors and may interact with histidine residues on OR4A16, potentially leading to a decreased affinity for its ligands and thus inhibiting its functional activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions are known to modulate the activity of various receptors. By binding to specific sites on OR4A16, zinc ions can alter the receptor conformation and inhibit its ability to activate the associated G-protein and subsequent signal transduction. | ||||||
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $89.00 $252.00 | 9 | |
Icilin is a synthetic super-agonist of TRPM8. Persistent activation of TRPM8 by icilin in olfactory neurons can inhibit OR4A16 activity by altering the calcium dynamics and signaling pathways within the neurons, leading to decreased sensitivity to odors. | ||||||
Thymol | 89-83-8 | sc-215984 sc-215984A | 100 g 500 g | $97.00 $193.00 | 3 | |
Thymol is known to modulate the activity of various ion channels including TRPM8. Given the co-expression with OR4A16, thymol-induced TRPM8 activation can lead to a decrease in OR4A16-mediated signaling due to changes in neuron membrane potentials and receptor desensitization. | ||||||
Allyl isothiocyanate | 57-06-7 | sc-252361 sc-252361A sc-252361B | 5 g 100 g 500 g | $43.00 $66.00 $117.00 | 3 | |
This compound is an agonist for TRPA1 channels. The activation of TRPA1 can inhibit OR4A16 by causing neuron desensitization and interfering with the receptor's normal response to its ligands, leading to decreased signal transduction efficiency. | ||||||
HC-030031 | 349085-38-7 | sc-203994 sc-203994A | 10 mg 50 mg | $87.00 $326.00 | 2 | |
HC-030031 is a selective antagonist of the TRPA1 channel. Despite being an antagonist, prolonged inhibition of TRPA1 can lead to compensatory mechanisms in sensory neurons that reduce OR4A16 activity, possibly due to changes in intracellular signaling cascades. | ||||||