OR2L5 Inhibitors
Chemical inhibitors of OR2L5 include a range of compounds that interfere with the receptor's ability to detect or respond to its ligands. Sulconazole and α-Naphthoflavone are known to inhibit cytochrome P450 enzymes, which can lead to a decrease in the bioactivation of odorant molecules, thereby reducing the activation of OR2L5. Ketoconazole, with its broad inhibitory effects on cytochrome P450 enzymes, can similarly reduce the metabolic clearance of odorants, potentially leading to lower activation of OR2L5. Quinidine specifically inhibits cytochrome P450 2D6, which may reduce the clearance of odorant molecules, affecting the functional response of OR2L5. Phenylthiourea acts by binding to copper in the olfactory receptor site, which can inhibit ligand-receptor interactions necessary for OR2L5 function. Cadmium chloride, by replacing zinc in zinc finger transcription factors, can alter gene expression and potentially interfere with the regulatory mechanisms controlling OR2L5 expression.
Furthermore, Tetraethylthiuram disulfide can inhibit the degradation of aldehydes, which are potential ligands for OR2L5, potentially leading to altered olfactory signaling. Methimazole can disrupt the functional expression of OR2L5 by altering the synthesis of thyroid hormones, which are known to influence the expression of various proteins. DDT, as an inhibitor of voltage-gated sodium channels, can affect the activation threshold of olfactory sensory neurons that express OR2L5. Chloroquine can alter the conformation of G-protein coupled receptors like OR2L5, inhibiting the receptor's ability to respond to odorants. 3-Methylindole, at high concentrations, can competitively inhibit the binding of ligands to OR2L5, thereby inhibiting the receptor's function. Vinclozolin can alter hormonal signaling pathways that regulate OR2L5 activity, as it is an antiandrogenic compound that inhibits androgen receptor signaling. These chemicals interfere with various stages of OR2L5's functional pathway, from ligand binding to gene expression regulation, affecting the receptor's ability to contribute to olfactory perception.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sulconazole | 61318-90-9 | sc-338599 | 100 mg | $1000.00 | 1 | |
Sulconazole, a known antifungal agent, inhibits the cytochrome P450 enzymes. OR2L5, being an olfactory receptor, may rely on the proper function of such enzymes for the bioactivation of odorant molecules. Inhibiting P450 enzymes can reduce the repertoire of odorant molecules, potentially decreasing OR2L5 activation. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Tetraethylthiuram disulfide is an inhibitor of aldehyde dehydrogenase (ALDH). Given that aldehydes are potential ligands for olfactory receptors including OR2L5, inhibiting their degradation can lead to altered olfactory signaling and thus, the inhibition of OR2L5 function due to the altered availability of its ligands. | ||||||
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $69.00 $110.00 | 4 | |
Methimazole acts by inhibiting the enzyme thyroid peroxidase. Thyroid hormones can influence the expression of various proteins, including olfactory receptors. Inhibition of thyroid hormone synthesis could, therefore, disrupt the functional expression of OR2L5 by altering the hormonal environment necessary for its expression or function. | ||||||
β-Naphthoflavone | 6051-87-2 | sc-205597 sc-205597A sc-205597B sc-205597C | 1 g 5 g 25 g 100 g | $32.00 $126.00 $587.00 $1615.00 | 2 | |
α-Naphthoflavone is a known inhibitor of cytochrome P450 1A1 enzyme. By inhibiting this enzyme, the bioactivation of certain odorant molecules could be impeded, possibly leading to a decreased functional response of OR2L5 to its ligands. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole is a broad cytochrome P450 enzyme inhibitor. By inhibiting these enzymes, the metabolic clearance of odorant molecules is potentially reduced, which could lead to a decrease in the activation of OR2L5 due to a change in the concentration of odorants. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $102.00 | 3 | |
Quinidine is known to inhibit cytochrome P450 2D6. Since OR2L5 is an olfactory receptor, and its function may be modulated by the availability of its ligands, inhibition of P450 2D6 may reduce the clearance of odorant molecules, thus potentially inhibiting the function of OR2L5. | ||||||
N-Phenylthiourea | 103-85-5 | sc-236086 | 100 g | $319.00 | ||
Phenylthiourea is an organosulfur compound which can bind to copper in the olfactory receptor site, potentially inhibiting the receptor's ability to bind to its ligands. This chemical interaction can lead to a functional inhibition of OR2L5 by preventing proper ligand-receptor binding. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is known to intercalate in DNA and has been shown to alter the olfactory signal transduction. By affecting the conformational states of the G-protein coupled receptors like OR2L5, chloroquine can inhibit the receptor's ability to respond to odorant binding. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Cadmium can replace zinc in various zinc finger transcription factors, potentially altering gene expression profiles. This could inhibit the function of OR2L5 by interfering with the transcriptional regulatory mechanisms that control the expression of proteins necessary for OR2L5's proper function. | ||||||
Vinclozolin | 50471-44-8 | sc-251425 | 250 mg | $23.00 | 1 | |
Vinclozolin is an antiandrogenic compound that inhibits androgen receptor signaling. Since hormonal balance can influence olfactory receptor function, disrupting androgen signaling could lead to a functional inhibition of OR2L5 by altering the hormonal environment that regulates its activity. | ||||||