OR1N2 Activators
Forskolin directly activate adenylyl cyclase resulting in increased intracellular cAMP. This elevation in cAMP can promote the signaling of GPCRs, including OR1N2, by enhancing the activity of protein kinase A (PKA) and the subsequent phosphorylation cascade that modulates GPCR function. Inhibitors of phosphodiesterase such as IBMX, caffeine, and theophylline serve to sustain heightened levels of cAMP by preventing its breakdown, thereby extending and intensifying the activation of GPCRs akin to OR1N2. PGE2 and histamine, through their respective receptors, can also regulate cAMP concentrations, which in turn can alter OR1N2 activity.
Nicotine has the capacity to influence the family of GPCRs by its interaction with nicotinic acetylcholine receptors, which can lead to diverse intracellular events affecting GPCR function. Capsaicin and menthol, known for their effects on TRP channels, can influence intracellular calcium levels, a secondary messenger that plays a critical role in GPCR signaling. L-Arginine is involved in the production of nitric oxide, which can influence GPCR signaling through cGMP-dependent pathways, potentially impacting OR1N2. Sodium butyrate can lead to changes in the expression of GPCRs, influencing the signaling of receptors like OR1N2. Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt is a non-hydrolyzable GTP analog that can activate G proteins, which are essential in GPCR signaling, thereby potentially enhancing the activity of OR1N2.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Blocks phosphodiesterase activity, which prevents cAMP degradation and can amplify OR1N2 receptor signaling. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
By inhibiting phosphodiesterases, caffeine increases cAMP levels, which can enhance the signaling of OR1N2. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
Increases cAMP levels by inhibiting phosphodiesterases, thereby can enhance OR1N2 receptor activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Acts on prostaglandin receptors to modify cAMP levels, which can influence OR1N2 signaling. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Influences cAMP levels via its action on histamine receptors, which can modify OR1N2 receptor activity. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Activates TRPV1 channels, impacting calcium signaling, which can modulate GPCR pathways, such as OR1N2. | ||||||
(−)-Menthol | 2216-51-5 | sc-202705 sc-202705A | 1 g 50 g | $20.00 $41.00 | 2 | |
Affects TRP channels, altering calcium levels, which can influence GPCR pathways including OR1N2. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
As a precursor to nitric oxide, it can affect GPCR signaling, such as OR1N2, through cGMP pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Modifies gene expression, potentially altering GPCR function and indirectly influencing OR1N2 signaling. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
A GTP analog that can activate G proteins, which may enhance signaling through the OR1N2 receptor. | ||||||