OR10R2 Inhibitors
OR10R2 inhibitors are chemical compounds specifically designed to modulate the activity of the olfactory receptor 10R2 (OR10R2), a G-protein coupled receptor (GPCR) found primarily in the olfactory system. Olfactory receptors such as OR10R2 belong to a large family of transmembrane proteins that play a critical role in the detection of volatile chemical compounds in the environment, which are then translated into sensory signals. OR10R2 is activated by specific odorant molecules that bind to the receptor's extracellular domains, inducing a conformational change that triggers downstream intracellular signaling pathways, primarily mediated by G-proteins. Inhibitors of OR10R2 function by either blocking the binding site of the receptor, preventing odorant molecules from interacting with it, or by allosterically modulating the receptor, thereby reducing its activation without directly competing for the binding site. This chemical inhibition can lead to a decrease or complete suppression of OR10R2's signaling capacity.
Structurally, OR10R2 inhibitors are often small organic molecules designed to fit into the receptor's binding pocket or to modify its active conformation through allosteric sites. These compounds can be identified or designed through computational modeling techniques such as molecular docking and virtual screening, which allow researchers to predict the interaction between the inhibitor and the receptor at an atomic level. Characterization of OR10R2 inhibitors typically involves the use of biochemical assays that measure the downstream signaling activity of the receptor, such as cAMP accumulation or calcium flux. Further structural studies, often using X-ray crystallography or cryo-electron microscopy, help to reveal the precise binding interactions between the inhibitor and OR10R2, contributing to the development of more selective and potent inhibitors.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamic Aldehyde inhibits Olfactory receptor 10R2 by binding to the receptor's ligand-binding site, which is typically used for odorant molecules. This binding leads to a conformational change in the receptor, preventing its normal function in olfactory signaling. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acetate inhibits Olfactory receptor 10R2 by altering the receptor's conformation through interaction with its zinc-binding sites. This change in conformation reduces the receptor's ability to bind to its natural ligands, thus inhibiting its olfactory signal transduction. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper(II) sulfate acts as an inhibitor of Olfactory receptor 10R2 by binding to specific sites on the receptor, leading to an alteration in its structure. This structural modification hinders the receptor's ability to interact with odorant molecules, inhibiting its sensory function. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
Sodium azide inhibits Olfactory receptor 10R2 by interfering with its metabolic processes. It disrupts the energy production in cells expressing the receptor, leading to a decrease in receptor functionality and thus inhibiting olfactory signal transduction. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol inhibits Olfactory receptor 10R2 by binding to the receptor and inducing a negative allosteric modulation. This binding changes the receptor's conformation, reducing its affinity for natural ligands and inhibiting its function in olfactory perception. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin inhibits Olfactory receptor 10R2 through a competitive inhibition mechanism. It binds to the same sites on the receptor as natural odorants, preventing their binding and thereby inhibiting the receptor's olfactory signaling ability. | ||||||
FCM Fixation buffer (10X) | sc-3622 | 10 ml @ 10X | $62.00 | 16 | ||
FCM Fixation buffer (10X) inhibits Olfactory receptor 10R2 by forming cross-links with amino acids in the receptor. These cross-links alter the receptor's structure, impairing its ability to bind to odorant molecules and thus inhibiting its sensory function. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $85.00 | ||
Lead acetate inhibits Olfactory receptor 10R2 by binding to specific sites within the receptor, which leads to a conformational change. This change decreases the receptor's ability to interact with its natural ligands, thereby inhibiting its olfactory signaling. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol inhibits Olfactory receptor 10R2 through a mechanism of competitive inhibition. It competes with natural odorants for binding sites on the receptor, decreasing the receptor's ability to detect these natural odorants and inhibiting its sensory role. | ||||||
Thiourea | 62-56-6 | sc-213038 | 50 g | $38.00 | ||
Thiourea inhibits Olfactory receptor 10R2 by interacting with specific functional groups in the receptor's structure. This interaction alters the receptor's conformation and impairs its ability to bind with odorants, thus inhibiting its olfactory function. | ||||||