Olfr99 Activators
Olfr99 is an olfactory receptor, a part of the extensive G-protein-coupled receptor (GPCR) family, which is essential for the detection and interpretation of olfactory signals. These receptors are specialized in sensing various odorant molecules and translating these chemical stimuli into neuronal signals, ultimately leading to the perception of odors. The functional activation of Olfr99, similar to other olfactory receptors, relies on the specific binding of odorant molecules to the receptor. This binding event induces conformational changes in Olfr99, crucial for the initiation of the signaling cascade. Upon ligand binding, Olfr99 undergoes a structural alteration, facilitating its interaction with G-proteins. This interaction is critical for the receptor's activation, leading to the activation of adenylate cyclase, an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP). The rise in cAMP levels is significant, as it activates protein kinase A (PKA), which then phosphorylates various targets within the cell. This cascade of events results in a range of cellular responses, leading to the neuronal response that constitutes the perception of smell. The specificity of the interaction between odorants and receptors like Olfr99 is key to the diversity and specificity of odor detection and discrimination. Each receptor is tuned to detect particular molecular features, allowing the olfactory system to discriminate among a vast array of different odors.
Understanding the activation mechanisms of receptors like Olfr99 provides valuable insights into the molecular basis of olfaction and GPCR signaling. This knowledge not only enhances our understanding of sensory biology but also has broader implications in physiology and pharmacology, as GPCRs are critical targets for various interventions. The primary focus here, however, is on the basic science of how Olfr99 functions within the olfactory system. This perspective is essential for advancing our comprehension of sensory systems and their role in interpreting external chemical cues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr99 through direct interaction with its ligand-binding domain, triggering a structural shift. This enables G-protein coupling and subsequent adenylate cyclase activation, resulting in increased cyclic AMP levels and PKA activation, functionally activating Olfr99. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate activates Olfr99 by binding to specific sites on the receptor, causing a conformational rearrangement. This rearrangement facilitates G-protein interaction and adenylate cyclase activation, increasing cyclic AMP production, leading to PKA activation and functional activation of Olfr99. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral activates Olfr99 through allosteric modulation, altering its conformation to enable effective G-protein coupling. This stimulates adenylate cyclase, elevating cyclic AMP levels, and activating PKA, thereby functionally activating Olfr99. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool activates Olfr99 by interacting with its ligand-binding domain, causing a structural change. This change leads to G-protein activation and adenylate cyclase stimulation, resulting in increased cyclic AMP levels and PKA activation, functionally activating Olfr99. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates Olfr99 by binding directly to the receptor, inducing a conformational change. This stimulates the G-protein signaling pathway, leading to adenylate cyclase activation, increased cyclic AMP levels, and subsequent PKA activation, thereby functionally activating Olfr99. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol activates Olfr99 through its interaction with specific binding sites, inducing structural alterations. These alterations facilitate G-protein coupling, leading to adenylate cyclase stimulation, increased cyclic AMP production, and PKA activation, functionally activating Olfr99. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol activates Olfr99 through allosteric modulation, altering the receptor's conformation. This alteration leads to G-protein coupling and activation, stimulating adenylate cyclase, increasing cyclic AMP levels, and activating PKA, thereby functionally activating Olfr99. | ||||||
Ethyl hexanoate | 123-66-0 | sc-235049 | 5 ml | $51.00 | ||
Ethyl hexanoate activates Olfr99 by binding to its orthosteric site, inducing a conformational change in the receptor. This leads to G-protein coupling, adenylate cyclase activation, increased cyclic AMP production, and PKA activation, functionally activating Olfr99. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $30.00 $59.00 | ||
Heptaldehyde activates Olfr99 through direct interaction with its binding domain, triggering a structural change. This change enables G-protein coupling and adenylate cyclase activation, increasing cyclic AMP production and PKA activation, thereby functionally activating Olfr99. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal activates Olfr99 by interacting with specific binding sites on the receptor, leading to a conformational shift. This shift facilitates G-protein coupling and activation, triggering adenylate cyclase, increasing cyclic AMP levels, and activating PKA, functionally activating Olfr99. | ||||||