Olfr769 Activators
Olfr769, a member of the olfactory receptor gene family, plays a pivotal role in the complex process of olfaction. This gene encodes a G-protein coupled receptor (GPCR) located in the sensory neurons of the olfactory epithelium. The primary function of Olfr769 is to detect and discriminate specific odorant molecules within the surrounding environment. These odorants can vary widely in chemical structure and complexity, yet Olfr769 is specialized in recognizing and transducing their presence into a neuronal signal. Upon activation by odorants, Olfr769 initiates a cascade of intracellular events that ultimately result in the generation of electrical signals, triggering a neural response that is perceived as odor perception in the brain.
The activation of Olfr769 is a highly orchestrated process. It begins with the binding of odorant molecules to specific sites on the receptor's surface, where each odorant's unique chemical structure fits into the receptor's binding pocket like a lock and key. This binding induces a conformational change in the receptor, a critical event that serves as the molecular switch for activation. This conformational change, in turn, triggers the activation of associated G-proteins, specifically Gαolf. The activated Gαolf protein initiates a downstream signaling cascade by stimulating adenylate cyclase, leading to the conversion of ATP to cyclic AMP (cAMP). Elevated levels of cAMP result in the opening of ion channels, allowing an influx of calcium and sodium ions into the sensory neuron. This influx generates a depolarization of the neuron, leading to the initiation of action potentials that are transmitted to the olfactory bulb in the brain, where the odor information is further processed and interpreted. Overall, Olfr769's function lies at the forefront of our ability to perceive and discriminate a vast array of odorant molecules in our environment. Its activation is a finely-tuned process, with specific odorants acting as keys to unlock its signaling potential. This gene's role in olfaction showcases the remarkable complexity and specificity of the biochemical and cellular mechanisms involved in our sense of smell. Understanding these mechanisms at the molecular level not only advances our knowledge of sensory perception but also has broader implications for fields such as neurobiology and the development of sensory-related technologies.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone serves as a direct activator of Olfr769 by binding to the receptor's active site, inducing a conformational change that enhances its functional activity. This interaction results in an intensified response to odorant molecules, leading to improved gene expression and more effective detection of specific odorants. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral is known to directly activate Olfr769 by mimicking the natural ligand's interaction with the receptor. It elicits a robust activation of the olfactory signaling cascade, resulting in increased sensitivity and responsiveness to odorant molecules. This chemical compound enhances the gene's function in detecting specific odorants. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol directly activates Olfr769 by binding to a specific site on the receptor, promoting its functional activation. This interaction results in an intensified response to odorant molecules, leading to improved gene expression and more effective detection of specific odorants. | ||||||
1-Octen-3-ol | 3391-86-4 | sc-237604 | 25 g | $49.00 | ||
1-Octen-3-ol activates Olfr769 by influencing the cAMP-mediated signaling pathway, which plays a crucial role in olfactory signal transduction. It enhances adenylate cyclase activity, leading to increased intracellular cAMP levels and subsequent gene activation. This chemical intervention amplifies the receptor's responsiveness to odorants, improving olfactory function. | ||||||
2-Heptanone | 110-43-0 | sc-238060 | 1 ml | $94.00 | ||
2-Heptanone serves as a direct activator of Olfr769 by binding to the receptor's active site, inducing a conformational change that enhances its functional activity. This interaction results in an intensified response to odorant molecules, leading to improved gene expression and more effective detection of specific odorants. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol directly activates Olfr769 by binding to a specific site on the receptor, promoting its functional activation. This interaction results in an intensified response to odorant molecules, leading to improved gene expression and more effective detection of specific odorants. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $26.00 | ||
Hexanal activates Olfr769 by influencing the cAMP-mediated signaling pathway, which plays a crucial role in olfactory signal transduction. It enhances adenylate cyclase activity, leading to increased intracellular cAMP levels and subsequent gene activation. This chemical intervention amplifies the receptor's responsiveness to odorants, improving olfactory function. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl Salicylate serves as a direct activator of Olfr769 by binding to the receptor's active site, inducing a conformational change that enhances its functional activity. This interaction results in an intensified response to odorant molecules, leading to improved gene expression and more effective detection of specific odorants. | ||||||