Olfr746 Activators
Olfr746 is an integral member of the olfactory receptor (OR) family, specifically classified as a G-protein coupled receptor (GPCR). These receptors are critical for the sense of smell, enabling the detection and discrimination of a vast array of odorant molecules. The unique structural and functional attributes of Olfr746 allow it to selectively interact with specific volatile compounds, playing a crucial role in the olfactory system's ability to discern and identify different scents. The receptor's ligand specificity is a key feature that contributes to the richness and diversity of the olfactory experience, enabling the detection of subtle nuances in scent compositions. The activation mechanism of Olfr746 involves the binding of an odorant molecule to the receptor, a highly specific interaction that is essential for initiating the olfactory signal transduction process. Upon binding of an appropriate ligand, such as the compounds listed in the table, Olfr746 undergoes a conformational change. This structural alteration is critical for activating the associated G-protein, marking the beginning of the intracellular signaling cascade. The activated G-protein triggers a series of biochemical events, often involving the production of second messengers like cyclic AMP (cAMP), which amplify the olfactory signal and lead to a cellular response. This response ultimately culminates in the transmission of neural signals to the brain, where they are interpreted as distinct odors.
The diverse range of chemicals identified as activators of Olfr746, including D-limonene, eucalyptol, and linalool, underscores the receptor's ability to respond to various odorants, each contributing to the complex tapestry of olfactory perception. The specific interactions between Olfr746 and these chemicals highlight the intricate nature of the olfactory system, where slight variations in the molecular structure of odorants can activate different receptors, contributing to the nuanced perception of smells. The function of Olfr746 in detecting these odorant molecules emphasizes the complexity and precision of the olfactory system, underscoring the importance of GPCRs in sensory perception. This process is not only vital for the perception of our environment but also plays a significant role in behaviors, memories, and emotions associated with different scents.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
D-Limonene, a major component in citrus oils, can activate Olfr746 by directly binding to it. This interaction leads to a conformational change in the receptor, activating the associated G-protein and triggering intracellular signaling pathways essential for the perception of citrus scents. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
Alpha-pinene, found in pine resin, can activate Olfr746. Its binding to the receptor induces a conformational change, leading to the activation of the G-protein, thereby initiating signaling pathways necessary for the perception of pine-like odors. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $44.00 | 2 | |
1,8-Cineole, a key component of eucalyptus oil, can activate Olfr746. Upon binding, it triggers a conformational change in the receptor, activating the G-protein and subsequent signaling pathways important for the olfactory perception of eucalyptus scents. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool, present in lavender and other aromatic plants, can activate Olfr746 by binding to the receptor. This interaction induces a conformational change, leading to G-protein activation and signaling pathways crucial for the detection of floral and spicy odors. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol, a monoterpenoid and alcohol, can activate Olfr746. By binding to the receptor, geraniol triggers a conformational change, activating downstream G-protein mediated signaling pathways and participating in the olfactory perception process. | ||||||
cis-3,7-Dimethyl-2,6-octadien-1-ol | 106-25-2 | sc-234382 | 5 ml | $51.00 | ||
cis-3,7-Dimethyl-2,6-octadien-1-ol, with a sweet rose-like aroma, can activate Olfr746 by directly interacting with the receptor. This binding induces a conformational change, leading to G-protein activation and signaling pathways important for the perception of rose-like odors. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal, a constituent of lemongrass oil, can activate Olfr746 through direct binding. Its interaction with the receptor activates the G-protein, initiating signaling pathways necessary for the perception of lemongrass scents. | ||||||
(+)-Carvone | 2244-16-8 | sc-239480 sc-239480A | 5 ml 25 ml | $33.00 $84.00 | 2 | |
Carvone, found in caraway and spearmint oils, can activate Olfr746. It binds to the receptor, causing a conformational change that activates the G-protein, thereby initiating signaling pathways for the perception of minty scents. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $576.00 $316.00 | ||
Anethole, a major component of anise and fennel, can activate Olfr746. By binding to the receptor, anethole triggers a conformational change, activating the G-protein and initiating signaling pathways important for perceiving anise-like aromas. | ||||||