Olfr429 Inhibitors
The Olfr429 olfactory receptor, a prominent member of the G-protein-coupled receptor (GPCR) family, orchestrates the initiation of neuronal responses pivotal for the perception of smells. Characterized by a 7-transmembrane domain structure, Olfr429 actively engages in the recognition and G protein-mediated transduction of odorant signals, contributing significantly to the intricate network of olfactory perception.
Inhibiting Olfr429 involves a nuanced interplay of direct and indirect mechanisms. Direct inhibitors, including camphor, hexanal, menthol, decanal, citral, and linalool, act by binding to Olfr429 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. On the other hand, indirect inhibitors, such as eugenol, thymol, isoeugenol, carvone, and methyl anthranilate, modulate the cyclic nucleotide signaling pathway associated with Olfr429. Their influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. This diverse array of inhibitors offers a multifaceted approach to interfering with Olfr429's role in odor recognition, presenting avenues for experimental exploration and validation of these inhibition mechanisms. Experimental validation is essential for confirming the efficacy of these inhibitors in practice and unraveling the complexities of olfactory signal transduction mediated by Olfr429.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr429. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $26.00 | ||
Hexanal serves as a direct inhibitor, binding to Olfr429 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Thymol | 89-83-8 | sc-215984 sc-215984A | 100 g 500 g | $97.00 $193.00 | 3 | |
Thymol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr429. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
(±)-Menthol functions as a direct inhibitor, binding to Olfr429 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Isoeugenol | 97-54-1 | sc-250186 sc-250186A | 5 g 100 g | $62.00 $52.00 | ||
Isoeugenol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr429. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Decanal | 112-31-2 | sc-234518 | 25 g | $43.00 | ||
Decanal serves as a direct inhibitor, binding to Olfr429 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral functions as a direct inhibitor, binding to Olfr429 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool serves as a direct inhibitor, binding to Olfr429 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Benzyl alcohol | 100-51-6 | sc-326216B sc-326216 sc-326216A | 250 ml 1 L 5 L | $31.00 $102.00 $408.00 | ||
Benzyl alcohol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr429. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||