Olfr208 Activators
Chemical activators of the olfactory receptor protein Olfr208 include a variety of organic compounds that initiate a signaling cascade by binding to the receptor. Benzaldehyde, citral, eugenol, isoamyl acetate, limonene, methyl salicylate, α-pinene, β-pinene, vanillin, geraniol, hexanal, and phenethyl alcohol are such chemicals that can activate Olfr208 through a similar mechanism. Upon exposure to these chemical activators, Olfr208 undergoes a conformational change that is pivotal for the subsequent activation of the G-protein. This change in the receptor's structure is a direct result of the binding of the activator to Olfr208's ligand-binding domain.
Once the ligand, which can be any of the aforementioned chemicals, is bound to Olfr208, the receptor protein engages its associated G-protein. This interaction between Olfr208 and the G-protein is a critical step that leads to the G-protein's activation. The active G-protein then triggers a series of intracellular signaling events, which typically involve the production of second messengers within the olfactory sensory neurons. These second messengers are responsible for propagating the signal that ultimately results in the generation of a neuronal response corresponding to the perception of odor. Each chemical activator, while similar in its ability to initiate the signaling cascade, may cause slightly different nuances in the conformational change of Olfr208, leading to the diverse range of odors that these compounds are associated with.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral is known to activate certain olfactory receptors, and by binding to Olfr208, it can induce a change in the receptor's structure. This change promotes the interaction with and activation of its G-protein, which then propagates the signal through downstream effectors in the signaling pathway. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates olfactory receptors like Olfr208 by binding to the ligand-binding domain, triggering a conformational change that leads to G-protein activation. This activation results in the initiation of downstream signaling cascades within olfactory sensory neurons. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate activates olfactory receptors like Olfr208 by binding to the receptor and causing a conformational shift, which enables the receptor to activate its associated G-protein. This activation triggers an intracellular signaling cascade culminating in a sensory response. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene can activate Olfr208 by interacting directly with its ligand-binding site, causing a conformational change that results in the activation of the G-protein signaling pathway. This pathway includes the production of second messengers that further propagate the signal within olfactory sensory neurons. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate activates olfactory receptors such as Olfr208 through the direct binding to the receptor, which leads to a conformational change and activation of the G-protein. This activation then triggers a cascade of intracellular events leading to a neuronal response. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
α-Pinene activates olfactory receptors like Olfr208 by binding and inducing a conformational change that leads to the activation of G-protein coupled signaling pathways. These pathways result in the generation of second messengers that propagate the signal to elicit a sensory response. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin activates Olfr208 by binding to its active site, which causes a conformational change in the protein structure, leading to the activation of the G-protein. This activation is the first step in a series of reactions that result in neuronal signaling. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol can activate olfactory receptors like Olfr208 by binding to the receptor's ligand-binding domain, thus inducing a conformational change that leads to activation of the G-protein, and subsequently, the olfactory signal transduction pathway. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal can activate olfactory receptors by binding to ligand-binding sites like those on Olfr208, causing a conformational change in the receptor. This change is critical for the activation of the G-protein and the subsequent signal transduction pathway that leads to the olfactory response. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
2-Phenylethanol activates olfactory receptors like Olfr208 through direct interaction with the receptor's ligand-binding domain, prompting a conformational change that activates the G-protein, which then initiates the downstream signaling necessary for olfactory perception. | ||||||