OGG2 Inhibitors
OGG2 inhibitors belong to a specialized class of chemical compounds designed to target a specific enzyme called 8-oxoguanine DNA glycosylase 2 (OGG2). This enzyme plays a crucial role in the repair of DNA damage caused by oxidative stress and reactive oxygen species. OGG2 is primarily involved in the base excision repair (BER) pathway, which is responsible for recognizing and removing damaged DNA bases, such as 8-oxoguanine (8-oxoG), from the genetic material. 8-oxoG is a common DNA lesion resulting from the oxidation of guanine, one of the four DNA bases. If not repaired, this lesion can lead to mutations, genomic instability, and potentially contribute to the development of various diseases, including cancer.
The role of OGG2 inhibitors is to selectively block or inhibit the activity of OGG2, thus impairing its ability to recognize and excise 8-oxoG from DNA. By interfering with this repair process, OGG2 inhibitors can potentially enhance the accumulation of 8-oxoG lesions in DNA, which may have downstream consequences in cellular processes. Researchers are interested in studying OGG2 inhibitors not only for their fundamental roles in understanding DNA repair mechanisms but also for their potential applications in various research areas, such as elucidating the link between DNA damage and disease development.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Exposure has been shown to decrease OGG1 expression in certain cell types, potentially through interference with cellular regulatory mechanisms. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $83.00 | ||
Lead exposure can lead to oxidative DNA damage and has been associated with reduced OGG1 expression and activity in some studies. | ||||||
Benzo[a]pyrene | 50-32-8 | sc-257130 | 1 g | $439.00 | 4 | |
A polycyclic aromatic hydrocarbon that can cause DNA damage; it might downregulate OGG1 expression as part of a broader disruption of cellular processes. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $87.00 $224.00 | ||
Has been associated with oxidative stress and reduced OGG1 activity; long-term exposure might lead to decreased expression through epigenetic changes or other mechanisms. | ||||||
Acrylamide Solution, 40% | 79-06-1 | sc-3721 | 1 L | $98.00 | ||
Can form adducts with DNA, potentially leading to decreased OGG1 activity and possibly reduced expression through disruption of normal cellular processes. | ||||||
FCM Fixation buffer (10X) | sc-3622 | 10 ml @ 10X | $61.00 | 16 | ||
Can cause DNA cross-linking and damage, potentially leading to decreased OGG1 activity, although its direct effects on OGG1 expression are not fully characterized. | ||||||
Dichloroacetic acid | 79-43-6 | sc-214877 sc-214877A | 25 g 100 g | $60.00 $125.00 | 5 | |
Has been shown to cause oxidative stress and DNA damage; prolonged exposure might lead to changes in OGG1 expression, although this relationship is not fully understood. | ||||||