OATP-D Inhibitors

OATP-D inhibitors, also known as organic anion-transporting polypeptide D inhibitors, belong to a class of chemical compounds designed to modulate the activity of OATP-D transporters in the human body. OATP-D, or organic anion-transporting polypeptide D, is a group of membrane proteins primarily located in the cell membranes of various tissues, including the liver, kidney, and intestine. These transporters play a pivotal role in the uptake and clearance of endogenous and exogenous compounds from the bloodstream. OATP-D inhibitors, therefore, serve as pharmacological agents that interact with these transporters, influencing their function and subsequently affecting the absorption, distribution, and elimination of various substrates.

OATP-D transporters is to facilitate the transport of a diverse range of molecules, including drugs, hormones, and xenobiotics, across biological membranes. By inhibiting these transporters, OATP-D inhibitors can modulate the pharmacokinetics of drugs and other compounds. This modulation can lead to altered drug bioavailability, potentially reducing the rate of drug absorption or increasing its elimination from the body. Consequently, OATP-D inhibitors have significant implications for drug-drug interactions, as they can either enhance or diminish the effects of co-administered drugs by affecting their uptake and distribution in target tissues.