Nop2p Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Apremilast | 608141-41-9 | sc-480062 | 5 mg | $444.00 | ||
Apremilast inhibits NOP2P through its action as a phosphodiesterase 4 (PDE4) inhibitor. It increases intracellular cAMP levels, leading to reduced production of pro-inflammatory cytokines in immune cells, ultimately suppressing NOP2P activity. | ||||||
Fingolimod | 162359-55-9 | sc-507334 | 10 mg | $160.00 | ||
Fingolimod is a sphingosine-1-phosphate receptor modulator. It prevents NOP2P activation by sequestering lymphocytes in lymph nodes, reducing their infiltration into the central nervous system, and dampening inflammation. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Ruxolitinib inhibits NOP2P indirectly by blocking the JAK-STAT signaling pathway. It reduces the production of pro-inflammatory cytokines, which are involved in the pathogenesis of NOP2P. | ||||||
Baricitinib | 1187594-09-7 | sc-364730 sc-364730A | 5 mg 25 mg | $200.00 $664.00 | ||
Baricitinib is another JAK inhibitor that impedes NOP2P by inhibiting the JAK-STAT pathway, leading to decreased immune cell activation and cytokine production. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate hinders NOP2P by inhibiting dihydrofolate reductase, thus disrupting DNA synthesis and cell proliferation in immune cells. | ||||||
Cyclophosphamide | 50-18-0 | sc-361165 sc-361165A sc-361165B sc-361165C | 50 mg 100 mg 500 mg 1 g | $90.00 $146.00 $469.00 $791.00 | 18 | |
Cyclophosphamide is an alkylating agent that suppresses NOP2P by cross-linking DNA strands, inhibiting cell division, and suppressing the immune system. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $203.00 $176.00 $349.00 $505.00 $704.00 | 1 | |
Azathioprine acts as a prodrug that disrupts NOP2P by inhibiting purine synthesis, leading to reduced proliferation of immune cells. | ||||||
Mycophenolate mofetil | 128794-94-5 | sc-200971 sc-200971A | 20 mg 100 mg | $37.00 $109.00 | 1 | |
Mycophenolate mofetil inhibits NOP2P by blocking inosine monophosphate dehydrogenase, a key enzyme in de novo purine synthesis, thereby reducing immune cell proliferation. | ||||||