NOMO Inhibitors

NOMO inhibitors, as a chemical class, are not well-defined due to the indirect nature of the inhibition mechanisms. These compounds are characterized by their ability to modulate signaling pathways that are either directly or indirectly related to the function of NOMO. Given that NOMO is thought to be associated with the nodal signaling pathway, the inhibitors listed target various components of the TGF-β superfamily signaling network, which includes nodal, activin, and BMP pathways. These pathways converge on a shared group of intracellular proteins, the SMADs, which transduce signals from the cell surface to the nucleus, regulating gene expression.

The compounds presented here are primarily kinase inhibitors that target the serine/threonine kinase receptors (ALKs) involved in the propagation of TGF-β family signals. By inhibiting these receptors, they can prevent the phosphorylation event that is necessary for the activation of SMAD proteins. Once activated, SMAD proteins form complexes that translocate to the nucleus and affect gene transcription. Therefore, by preventing SMAD activation, these inhibitors can suppress the downstream signaling events that NOMO might modulate.