Nmi Activators
Nmi Activators are a class of compounds that can activate or enhance the functional activity of Nmi by triggering specific signaling pathways or biological processes. Forskolin, by raising cAMP levels, directly activates protein kinase A (PKA), which can phosphorylate various targets, potentially enhancing Nmi's activity. Similarly, phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), leading to phosphorylation events that may facilitate the activation of Nmi. Ionomycin, as a calcium ionophore, can elevate intracellular calcium levels, which in turn may trigger calcium-dependent pathways to activate Nmi. Meanwhile, EGF initiates the MAPK/ERK pathway, potentially influencing Nmi's activity through downstream phosphorylation events.
The insulin-triggered PI3K/AKT signaling pathway may also play a role in enhancing Nmi activity. Dibutyryl-cAMP, a cell-permeable cAMP analog, directly activates PKA, which could influence Nmi activity through phosphorylation. Similarly, A23187 raises intracellular calcium levels, potentially engaging Nmi activity through calcium-mediated signaling. Isoproterenol, a beta-adrenergic agonist, increases cAMP and thereby activates PKA, possibly affecting Nmi.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to an increase in cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various targets, potentially enhancing Nmi's functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in numerous signaling cascades. Activated PKC may lead to phosphorylation events that enhance the activity of Nmi through downstream signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that elevates intracellular calcium levels, triggering calcium-dependent pathways that may include the activation of Nmi through calcium signaling. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin binds to its receptor and activates the PI3K/AKT signaling pathway, potentially resulting in enhanced Nmi activity through secondary messenger systems and phosphorylation cascades. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that permeates cell membranes, directly activating PKA, which could accelerate Nmi's functional activity through phosphorylation of associated proteins. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore that raises intracellular calcium levels, possibly activating Nmi through calmodulin-dependent or other calcium-mediated signaling processes. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, consequently activating PKA. PKA activation can lead to the enhancement of Nmi's activity through phosphorylation mechanisms. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, which may lead to the stabilization and activation of proteins in pathways associated with Nmi, enhancing its functional activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins, which could enhance the activity of Nmi. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases, potentially resulting in an upregulation of Nmi's activity through stress response pathways. | ||||||