NKG2-I Activators
Activators of NKG2-I are chemicals that can influence the activation state of natural killer (NK) cells by modulating intracellular signaling pathways or affecting the expression of receptors and their ligands. The compounds listed above have been identified based on their potential to indirectly influence theactivation of NKG2-I, a protein linked with NK cell function and the innate immune response. The activation of NKG2-I is not directly influenced by small molecules but can be indirectly affected through modulation of the cellular environment, gene expression, or signaling pathways that are crucial for NK cell function. The chemical class of NKG2-I Activators encompasses a broad range of compounds, which include lipid-derived molecules like Prostaglandin E2 and Arachidonic Acid, which can affect the expression of activating ligands for receptors related to the NKG2 family. These molecules may impact the immune surveillance activities of NK cells by modulating the expression of activating receptors or their ligands, leading to altered immune cell responses. Micronutrients such as Zinc and Vitamin D3 are also critical, as they can affect the immune system's functionality, potentially modifying the expression and responsiveness of receptors such as NKG2-I.
Additionally, secondary messengers like IP3 may indirectly contribute to the activation of NKG2-I by facilitating intracellular calcium mobilization, a pivotal step in NK cell activation. Diterpenes like Forskolin, which increase intracellular cAMP levels, and biogenic amines such as Histamine can also modulate immune cell function, possibly influencing NK receptor activity. Phytochemicals such as Curcumin and Resveratrol are known for modulating immune responses and could affect NK cell activity and receptor expression. Capsaicin and Lithium Chloride, though not directly linked to NKG2-I, can alter immune cell activation states, thereby potentially impacting the functional status of NK receptors. These diverse compounds help create an environment conducive to the activation of NKG2-I, although not through direct binding or stimulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) is a lipid compound that can indirectly activate NKG2D, a receptor related to NKG2-I, by modulating the expression of its ligands on the surface of stressed cells. PGE2 can down-regulate NKG2D ligand expression, which can cause an initial suppression of NKG2D-mediated responses, potentially followed by a rebound overexpression and stronger activation of the receptor. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can enhance immune function by modulating various cellular processes. While direct activation of NKG2-I by zinc has not been shown, zinc supplementation can influence immune cell function and could lead to the upregulation of activating receptors, such as those in the NKG2 family, by altering intracellular signalling pathways. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3, or cholecalciferol, modulates immune responses. It can indirectly impact the function of NK cells, potentially affecting the expression and activation of receptors such as NKG2-I. Vitamin D3 enhances the transcription of genes involved in immune surveillance, which might include genes that regulate the expression and function of NKG2-I. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid is a fatty acid that serves as a precursor for eicosanoids, which can modulate immune cell function. Through its metabolites, it may influence the activation and function of natural killer (NK) cells and their receptors, such as NKG2-I, by affecting the inflammatory response and acting on key signalling pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of Vitamin A, modulates immune function and could affect the expression of NKG2-I or related receptors on NK cells. It has been shown to regulate gene expression and could potentially enhance the activation of NK cells by increasing the expression of activating receptors or their ligands. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine is a biogenic amine that, through its receptors on immune cells, can influence the activation and cytotoxicity of NK cells. Although a direct link to NKG2-I activation is not established, histamine can modulate other receptors that function in concert with NKG2-I. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a bioactive component of turmeric, can modulate immune responses by affecting the proliferation, activation, and cytokine production of immune cells. While it does not directly activate NKG2-I, curcumin can modulate pathways that affect NK cell receptor expression and function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenol that can exert modulatory effects on immune cells. It has been found to affect NK cell cytotoxicity and could potentially influence the activation of receptors on NK cells such as NKG2-I through its action on various cellular signalling pathways. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin, the active component in chili peppers, has been shown to affect immune responses. While a direct link to NKG2-I is not established, capsaicin can influence the activation state of immune cells, potentially altering the expression or function of receptors like NKG2-I. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can impact immune cell signalling pathways, particularly those involving glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 by lithium could lead to changes in the activation status of natural killer cells, which might affect the functional state of receptors such as NKG2-I. | ||||||