NIPA1 Activators
Chemical activators of NIPA1 can function through various cellular pathways to indirectly enhance the activity of this magnesium transporter. Magnesium sulfate, by raising the extracellular magnesium concentration, necessitates the activation of NIPA1 to maintain the delicate intracellular magnesium levels essential for numerous biological processes. Similarly, neomycin, with its membrane-disruptive properties, may prompt cellular mechanisms to activate NIPA1 as a compensatory response to restore disrupted ionic gradients. Insulin, well-known for its role in PI3K/Akt signaling related to cell growth and metabolic regulation, can increase the cellular demand for magnesium, hence indirectly stimulating NIPA1 to facilitate the influx of this vital ion. The influx of magnesium is critical for ATP-dependent processes, and as such, increased levels of ATP itself may signal for the enhanced activity of NIPA1 to meet this demand.
Further, EGF activates the MAPK/ERK pathway, which is involved in cellular proliferation, potentially leading to an increased requirement for magnesium. This could indirectly lead to the upregulation of NIPA1 activity to supply the necessary magnesium. Calcitriol, the biologically active form of vitamin D3, known to modulate calcium and magnesium balance, could also indirectly necessitate the activation of NIPA1 to synchronize with the shifts in calcium homeostasis. Forskolin and caffeine, through their elevation of cAMP levels, could signal for the activation of NIPA1 as part of a broader cellular response to regulate ionic balance and cellular signaling. Nitric oxide donors, by altering cellular signaling pathways, can create a physiological context in which the activity of NIPA1 is upregulated to adjust intracellular magnesium levels that are crucial for effective signal transduction. Lastly, antioxidants like glutathione maintain the cellular redox state and may require the activation of NIPA1 during oxidative stress to ensure ionic balance, while osmotic shock agents like mannitol may activate NIPA1 in response to changes in cellular osmolarity to restore ionic equilibrium.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
By increasing extracellular magnesium concentration, it can indirectly stimulate NIPA1 to maintain intracellular magnesium homeostasis. | ||||||
Neomycin sulfate | 1405-10-3 | sc-3573 sc-3573A | 1 g 5 g | $27.00 $35.00 | 20 | |
As a polycationic aminoglycoside, it can disrupt membrane potential, possibly triggering compensatory mechanisms involving NIPA1 activation to restore ionic balance. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Stimulates PI3K/Akt signaling, which is involved in cell growth and survival, potentially enhancing the activity of magnesium transporters like NIPA1 for cellular function. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
Modulates calcium and magnesium balance; might indirectly enhance NIPA1 function to regulate magnesium homeostasis in response to altered calcium levels. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
Cellular energy currency; increased ATP levels may indirectly increase NIPA1 activity to meet the energetic demands of magnesium-dependent processes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase and increases cAMP, which might indirectly stimulate NIPA1 as part of a cellular response to maintain ionic balance and signaling. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Inhibits phosphodiesterases leading to increased cAMP, which could indirectly increase NIPA1 activity to regulate intracellular magnesium levels for signal transduction. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Donors of nitric oxide can alter cellular signaling pathways, potentially increasing NIPA1 activity to adjust intracellular magnesium levels involved in such signaling. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
As an antioxidant, it maintains cellular redox state, which might indirectly necessitate the activation of NIPA1 for ionic balance during oxidative stress. | ||||||
D(−)Mannitol | 69-65-8 | sc-203020A sc-203020 | 50 g 100 g | $10.00 $19.00 | 2 | |
Inducing osmotic stress can alter cellular ionic concentrations, potentially triggering NIPA1 activation to restore ionic equilibrium. | ||||||