NHEDC1 Inhibitors
NHEDC1 inhibitors belong to a chemical class that primarily targets the NHEDC1 enzyme, playing a pivotal role in cellular processes. The NHEDC1 enzyme, also known as NHE1 (Sodium-Hydrogen Exchanger 1), is integral in maintaining cellular pH homeostasis by facilitating the exchange of sodium ions for protons across the cell membrane. This exchange mechanism is crucial for regulating intracellular pH and maintaining cellular functions. NHEDC1 inhibitors, therefore, act by disrupting this exchange process, potentially impacting various cellular pathways and functions associated with pH regulation.
The chemical structure of NHEDC1 inhibitors is designed to interact specifically with the NHEDC1 enzyme, hindering its activity and consequently affecting the sodium-proton exchange dynamics. Through this targeted mechanism, NHEDC1 inhibitors can modulate intracellular pH levels, which may have implications for cellular processes such as cell proliferation, migration, and survival. The intricate design of these inhibitors allows for a selective and potent inhibition of NHEDC1, making them valuable tools for researchers studying the intricate details of cellular pH regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride is a potassium-sparing diuretic that acts as an inhibitor of epithelial sodium channels (ENaCs). NHEDC1, being a sodium channel, could be inhibited by amiloride, leading to reduced sodium transport activity. | ||||||
Triamterene | 396-01-0 | sc-213103A sc-213103 | 1 g 5 g | $22.00 $53.00 | ||
Triamterene is another potassium-sparing diuretic that inhibits sodium reabsorption in the kidney. Its inhibition of sodium channels could extend to NHEDC1, leading to a decrease in its functional activity. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $54.00 $235.00 $326.00 $551.00 $969.00 | ||
Hydrochlorothiazide is a thiazide diuretic that indirectly influences sodium transport by inhibiting the Na+/Cl- cotransporter. This could reduce the activity of NHEDC1 by decreasing the overall sodium gradient that drives NHEDC1 function. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone is an aldosterone antagonist with indirect effects on sodium transport. By inhibiting aldosterone's action, it may reduce the expression or activity of sodium channels like NHEDC1. | ||||||
Eplerenone | 107724-20-9 | sc-203943 sc-203943A | 10 mg 50 mg | $108.00 $612.00 | 4 | |
Eplerenone is a selective aldosterone receptor antagonist that would indirectly decrease NHEDC1 activity by reducing aldosterone-mediated transcription of sodium channels. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine inhibits voltage-gated sodium channels. By blocking sodium ion flow, lidocaine could reduce NHEDC1 activity if NHEDC1 operates under similar mechanisms. | ||||||
Ranolazine | 95635-55-5 | sc-212769 | 1 g | $107.00 | 3 | |
Ranolazine is a drug known to block late phases of the sodium current in cardiac cells. If NHEDC1 has similar properties, ranolazine could decrease its activity by altering sodium ion transport. | ||||||